Effect of FIGF overexpression on liver cells transforming to insulin-producing cells

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dc.contributor.authorHe, Yaqinen_US
dc.contributor.authorXie, Xiaoliangen_US
dc.contributor.authorLi, Xiaoyanen_US
dc.contributor.authorRong, Shikuoen_US
dc.contributor.authorLi, Yukuien_US
dc.contributor.authorLu, Zhenhuien_US
dc.date.accessioned2020-11-18T10:14:14Z
dc.date.available2020-11-18T10:14:14Z
dc.date.issued2019-12
dc.description.abstractLimitation in the number of insulin-producing pancreatic b-cells is a typical feature of diabetes. It has been indicated thatactivating pancreatic transcription factors can promote the transformation of hepatocytes into insulin-secreting b-like cells,indicating that direct hepatocyte differentiation seems promising as a treatment for diabetes. Nevertheless, the reprogramming efficiency still remains low. Our previous study found that the expression of c-fos-induced growth factor (FIGF)was increased in the pancreatic tissues in partial pancreatectomy mice compared to that in normal mice. Here, we observedthat treatment with Ad-FIGF was found to enhance MafA and Ngn3-induced reprogramming of BNL CL.2 cells to b-likecells with the ability of secreting insulin. And FIGF overexpression increased the levels of histone H3/H4 acetylation atMafA and Ngn3 promoter regions in BNL CL.2 cells. Importantly, in vivo study further confirmed that forced expression ofFIGF facilitated the insulin expression and decreased the blood glucose levels in STZ mice. These results strengthen thepossibility of developing cell-based therapies for diabetes through utilizing b-like cells derived from non-insulin-secretingcells.en_US
dc.identifier.affiliationsSurgery Laboratory, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, Chinaen_US
dc.identifier.affiliationsDepartment of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China College of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, Ningxia, Chinaen_US
dc.identifier.affiliationsDepartment of Urology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, Chinaen_US
dc.identifier.affiliationsCollege of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, Ningxia, Chinaen_US
dc.identifier.affiliationsNingxia Medical University, Yinchuan 750004, Ningxia, Chinaen_US
dc.identifier.affiliationsDepartment of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, Chinaen_US
dc.identifier.citationHe Yaqin, Xie Xiaoliang, Li Xiaoyan, Rong Shikuo, Li Yukui, Lu Zhenhui. Effect of FIGF overexpression on liver cells transforming to insulin-producing cells. Journal of Biosciences. 2019 Dec; 44(6): 1-8en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214216
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber6en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-019-9965-4en_US
dc.subjectC-fos-induced growth factor (FIGF)en_US
dc.subjectdiabetesen_US
dc.subjecthistone H3/H4 acetylationen_US
dc.subjectMafA and Ngn3en_US
dc.titleEffect of FIGF overexpression on liver cells transforming to insulin-producing cellsen_US
dc.typeJournal Articleen_US
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