Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors.

dc.contributor.authorTrongtokit, Yuwadeeen_US
dc.contributor.authorRongsriyam, Yuphaen_US
dc.contributor.authorKomalamisra, Narumonen_US
dc.contributor.authorKrisadaphong, Panvipaen_US
dc.contributor.authorApiwathnasorn, Chamnarnen_US
dc.date.accessioned2009-05-27T15:21:15Z
dc.date.available2009-05-27T15:21:15Z
dc.date.issued2004-06-05en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractOils of Syzygium aromaticum (clove) and Zanthoxylum limonella (makaen), widely used essential oils for dental caries or flavoring of food in Thailand, were prepared as 10 experimental repellent products in gel or cream form against Aedes aegypti, Culex quinquefasciatus, and Anopheles dirus under laboratory conditions, using the human-arm-in-cage method. Two products that gave the longest-lasting complete protection were selected to examine their repellency against a variety of mosquito species under field conditions. In laboratory tests, 0.1 g of each product was applied to 3x10 cm of exposed area on a volunteer's forearm, while in field trials, 1.0 g was applied to each volunteer's leg (from knee to ankle). In the laboratory, the gel dosage form contained 20% clove oil (Gel B) or 10% clove plus 10% makaen oil mixture (Gel E) were promising plant-based repellents against three mosquito species and gave significantly longer complete protection times of 4-5 hours than all other developing products. Therefore, their efficacy in the field was evaluated. Under field conditions, Gel E showed complete protection for 4 hours and gave 95.7% repellency after 5 hours application, whereas Gel B and 20% deet (di-methyl benzamide) provided only 86.8 and 82.7% repellency after treatment, respectively against Ae. aegypti, daytime-biting mosquitos. For nighttime-biting, the 3 repellents under development yielded equally excellent (average 97.1%) repellency for 5 hours against the predominant Cx. quinquefasciatus and Mansonia uniformis, but they gave 89.0% repellency against Cx. tritaeniorhynchus and Cx. gelidus. This finding demonstrated the effectiveness of Gel B and Gel E products for possible use by low-income rural communities against various mosquito species.en_US
dc.description.affiliationDepartment of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationTrongtokit Y, Rongsriyam Y, Komalamisra N, Krisadaphong P, Apiwathnasorn C. Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Jun; 35(2): 325-33en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32572
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2004_35_2/15-3327.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshClove Oil --administration & dosageen_US
dc.subject.meshCulicidae --drug effectsen_US
dc.subject.meshDrug Evaluationen_US
dc.subject.meshEugenia --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshInsect Repellents --administration & dosageen_US
dc.subject.meshMalaria --parasitologyen_US
dc.subject.meshMosquito Control --methodsen_US
dc.subject.meshOils, Volatile --administration & dosageen_US
dc.subject.meshPlant Oils --administration & dosageen_US
dc.subject.meshThailanden_US
dc.subject.meshZanthoxylum --chemistryen_US
dc.titleLaboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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