Cardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium.

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dc.contributor.authorMohire, N Cen_US
dc.contributor.authorSalunkhe, V Ren_US
dc.contributor.authorBhise, S Ben_US
dc.contributor.authorYadav, A Ven_US
dc.date.accessioned2009-05-28T12:15:59Z
dc.date.available2009-05-28T12:15:59Z
dc.date.issued2007-06-26en_US
dc.description.abstractThe present study was undertaken to evaluate cardiotonic activity of aqueous extract of heartwood of P. marsupium. This plant species contains 5,7,2-4 tetrahydroxy isoflavone 6-6 glucoside which are potent antioxidant and are believed to prevent cardiovascular diseases. Cardiotonic effect of aqueous extract of heartwood of P. marsupium was studied by using isolated frog heart perfusion technique (IFHP). Calcium free Ringer solution was used as vehicle for administration of aqueous extract of P. marsupium as a test extract and digoxin as a standard. A significant increase in height of force of contraction (positive inotropic effect) and decrease in heart rate (negative chronotropic effect) at a very low concentration (0.25 mg/ml) was observed with test extract as compared to the same dose of a standard digoxin. The present results indicated that a significant increase in height of force of contraction with decrease in heart rate was observed as the dose of test extract increased. The test extract produced cardiac arrest at 4 mg/ml, a higher concentration, as compared to standard, digoxin (0.5 mg/ml). Compared to digoxin, a drug with narrow therapeutic window, P. marsupium showed wide therapeutic window.en_US
dc.description.affiliationGovernment College of Pharmacy, Vidyanagar, Karad 415 124, India.en_US
dc.identifier.citationMohire NC, Salunkhe VR, Bhise SB, Yadav AV. Cardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium. Indian Journal of Experimental Biology. 2007 Jun; 45(6): 532-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57847
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5275/1/IJEB%2045%286%29%20532-537.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiotonic Agents --pharmacologyen_US
dc.subject.meshDigoxin --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshMyocardial Contraction --drug effectsen_US
dc.subject.meshPlant Extracts --chemistryen_US
dc.subject.meshPterocarpus --chemistryen_US
dc.subject.meshRanidaeen_US
dc.subject.meshWater --chemistryen_US
dc.titleCardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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