Clinical significance of vanillylmandelic acid in neuroblastoma

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dc.contributor.authorRathnakumar, Geetaen_US
dc.contributor.authorBolkar, Smitaen_US
dc.contributor.authorGhosh, Kinjalkaen_US
dc.contributor.authorInamdar, Nitinen_US
dc.date.accessioned2020-04-09T07:43:25Z
dc.date.available2020-04-09T07:43:25Z
dc.date.issued2020-01
dc.description.abstractBackground: The second most common solid tumor in children is Neuroblastoma (NB). In about 90% of cases of NB, elevated levels of catecholamines or its metabolites are found in the urine or blood which includes Vanillylmandelic Acid (VMA) and Homovanillic Acid (HVA). Ferritin, Neuron-Specific Enolase (NSE) and Lactate Dehydrogenase (LDH) are commonly assessed in children suspected to have NB, and the levels of these markers are commonly used for differential diagnosis. Multiple clinical and imaging tests are needed for accurate patient assessment. Iodine 123(123I) Metaiodobenzylguanidine (MIBG) is the first-line functional imaging agent used in neuroblastoma imaging. To evaluate the utility of these marker present study was undertaken with 91 NB patients and 40 normal healthy control.Methods: The study comprised of blood samples and 24 hour抯 urine sample from 40 normal healthy subjects and 91 untreated patients with histologically proven Stage III and IV NB cases referred to our institute. Method used for NSE was Enzyme Immunoassay (Elisa), serum Ferritin was MIA, LDH-photometry and VMA by Column Chromatography.Results: Amongst the parameters studied VMA showed highest sensitivity (91%), specificity (94.4%) positive predictive value (97.8%) and 85% negative predictive value at the cut off levels of 7mg/ ml of creatinine as compared to other studied parameters.Conclusions: This study suggests that the detection of VMA in combination with routine histological examination, MIBG scan, serum NSE and LDH may improve the diagnosis of Neuroblastoma.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Tata Memorial Hospital Parel east, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationRathnakumar Geeta, Bolkar Smita, Ghosh Kinjalka, Inamdar Nitin. Clinical significance of vanillylmandelic acid in neuroblastoma. International Journal of Advances in Medicine. 2020 Jan; 7(1): 84-89en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194540
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20195650en_US
dc.subjectHomovanillic aciden_US
dc.subjectLactate dehydrogenaseen_US
dc.subjectMetaiodobenzylguanidineen_US
dc.subjectNeuroblastomaen_US
dc.subjectNeuron-specific enolaseen_US
dc.subjectVanillylmandelic aciden_US
dc.titleClinical significance of vanillylmandelic acid in neuroblastomaen_US
dc.typeJournal Articleen_US
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