In vivo Evaluation of Hypolipidemic Potentials of Bacillus Species Isolated from Fermented Locust Bean (Parkia fillicoides Welw) Seeds (Iru).

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dc.contributor.authorAderiye, B I
dc.contributor.authorDavid, O M
dc.date.accessioned2015-09-02T11:23:24Z
dc.date.available2015-09-02T11:23:24Z
dc.date.issued2013-10
dc.description.abstractAim: Iru is a popular West Africa fermented soup condiment which is also consumed without cooking as snack. This product is mainly fermented by Bacillus species. The hypolipidemic activities of Bacillus spp. isolated from iru have not been documented hence the aim of this study. Place and Duration of Study: Iru sample was bought in an open market in Iworoko-Ekiti, Nigeria and transferred to the Laboratory of the Department of Microbiology, Ekiti State University, Nigeria where other studies were carried out. The study was conducted between January and June, 2012. Methodology: The properties and in vivo hypolipidemic potential of Bacillus species from iru were investigated using standard microbiological and haematological methods. Results: The cell free extracts of the Bacillus spp. did not produce significant inhibition on the selected Gram positive and Gram negative pathogens. Qualitative enzyme screening of the isolates showed all were haemolysin negative. Only B. subtilis was positive to gelatinase while all the isolates produced catalase and lipase. The average weight of the animals after inducement of hyper-cholesterolemia ranged between 60.5g - 95.3g. The amount of serum total cholesterol (TC) in the animals ranged between 124.9 mg/dl – 127.4 mg/dl while that of serum triglycerides (TG), high density protein (HDL) and low density protein (LDL) were 122.5 – 155.3 mg/dl, 10.0 – 15.3 mg/dl and 76.6 – 81.0 mg/dl respectively. The weights of hyper-cholesterolemia induced rats challenged with different species of Bacillus were relatively lower than those in the control group and also differ significantly from the control, at p˂ 0.05. The values of TC, TG, and LDL were highest in the control (saline) group while the values in the treatment group ranged between 121.3 ± 1.5 and 102.3 ± 6.8 mg/dl for TC. The treatment groups recorded lower values of values for TG (104.7 ± 1.6 - 117.4 ± 9.1 mg/dl) and LDL (42.6 ±7.4 - 59.0 ± 10.2 mg/dl) compared to the control. B. subtilis had the highest values of TC but least amount of LDL. TG in all the groups was higher than TC, HDL and LDL. The TC/HDL and the LDL/HDL of the animals in the iru group was higher than the other treatment groups but lower than the control. Conclusion: Compared to the control, hypolipidemic activities of B. lichenliformis was the best followed by B. subtilis. Iru had the least hypo-cholesterolemic effect.en_US
dc.identifier.citationAderiye B I, David O M. In vivo Evaluation of Hypolipidemic Potentials of Bacillus Species Isolated from Fermented Locust Bean (Parkia fillicoides Welw) Seeds (Iru). British Microbiology Research Journal. 2013 Oct; 3(4): 574-584.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162944
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/1864en_US
dc.subjectIruen_US
dc.subjecthypolipidemiaen_US
dc.subjectBacillus spp.en_US
dc.subjectprobioticsen_US
dc.subjectcholesterolemiaen_US
dc.subjectlipoproteinen_US
dc.subject.meshBacillus --isolation & purification
dc.subject.meshBacillus --metabolism
dc.subject.meshBacillus --physiology
dc.subject.meshFabaceae --chemistry
dc.subject.meshFabaceae --microbiology
dc.subject.meshFermentation
dc.subject.meshHypercholesterolemia
dc.subject.meshHypolipidemic Agents --chemistry
dc.subject.meshHypolipidemic Agents --pharmacology
dc.subject.meshLipid Metabolism
dc.subject.meshLipoproteins
dc.subject.meshPlant Extracts --chemistry
dc.subject.meshPlant Extracts --microbiology
dc.titleIn vivo Evaluation of Hypolipidemic Potentials of Bacillus Species Isolated from Fermented Locust Bean (Parkia fillicoides Welw) Seeds (Iru).en_US
dc.typeArticleen_US
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