Ameliorative effect of Luffa acutangula Roxb. on doxorubicin induced cardiac and nephrotoxicity in mice.

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dc.contributor.authorJadhav, Vishal B
dc.contributor.authorThakare, Vishnu N
dc.contributor.authorSuralkar, Anupama A
dc.contributor.authorNaik, Suresh R
dc.date.accessioned2013-07-30T06:26:22Z
dc.date.available2013-07-30T06:26:22Z
dc.date.issued2013-02
dc.description.abstractThe present study reports protective effect of hydro-alcoholic extract of Luffa acutangula (HAELA) on doxorubicin (DXR) induced cardio and nephro toxicity in mice by studying various serum biomarkers, antioxidants in target organs and histoarchitecture alterations. Pretreatment with HAELA reversed significantly the elevated serum biomarkers, alanine amino transferase, lactate dehydrogenase and creatinine phosphokinase in heart and kidney in DXR treated mice. In addition, HAELA treatment inhibited elevated malondialdehyde formation and restored the depleted glutathione, catalase, superoxide dismutase in heart and kidney tissue. The altered histoarchitecture of heart and kidney tissue due to DXR treatment were also improved with HAELA. The protective activity observed with HAELA on DXR induced cardio and nephrotoxicity in mice was found to be related to its antioxidant property which finally results in membrane stabilization.en_US
dc.identifier.citationJadhav Vishal B, Thakare Vishnu N, Suralkar Anupama A, Naik Suresh R. Ameliorative effect of Luffa acutangula Roxb. on doxorubicin induced cardiac and nephrotoxicity in mice. Indian Journal of Experimental Biology. 2013 Feb; 51(2): 149-156.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147578
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/15937en_US
dc.subjectAntioxidantsen_US
dc.subjectBiomarkersen_US
dc.subjectCardioprotectiveen_US
dc.subjectDoxorubicinen_US
dc.subjectLuffa acutangulaen_US
dc.subjectNephroprotective activityen_US
dc.subject.meshAdministration, Oral
dc.subject.meshAnimals
dc.subject.meshAntioxidants --metabolism
dc.subject.meshBiological Markers --blood
dc.subject.meshCardiovascular Diseases --blood
dc.subject.meshCardiovascular Diseases --drug therapy
dc.subject.meshDoxorubicin
dc.subject.meshFemale
dc.subject.meshKidney --drug effects
dc.subject.meshKidney --pathology
dc.subject.meshKidney Diseases --blood
dc.subject.meshKidney Diseases --drug therapy
dc.subject.meshLuffa --chemistry
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMyocardium --pathology
dc.subject.meshPhytotherapy
dc.subject.meshPlant Extracts --administration & dosage
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Extracts --therapeutic use
dc.subject.meshStaining and Labeling
dc.subject.meshToxicity Tests, Acute
dc.titleAmeliorative effect of Luffa acutangula Roxb. on doxorubicin induced cardiac and nephrotoxicity in mice.en_US
dc.typeArticleen_US
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