Infusion of low-dose vasopressin improves left ventricular function during separation from cardiopulmonary bypass: A double-blind randomized study.

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dc.contributor.authorElgebaly, Ahmed Said
dc.contributor.authorSabry, Mohab
dc.date.accessioned2012-07-19T04:36:39Z
dc.date.available2012-07-19T04:36:39Z
dc.date.issued2012-04
dc.description.abstractWe aimed to investigate whether low-dose vasopressin administered to patients undergoing coronary artery bypass grafting (CABG) surgery with preexisting mild to moderate systolic dysfunction can produce sustained improvement in cardiac function. This double-blind randomized study was conducted in a hospital where a single anesthetic and surgical team performed elective CABG. Twenty patients aged 32-61 years who underwent elective CABG between January 2007 and December 2007 were enrolled in this study. The patients randomly received either vasopressin 0.03 IU/min (Group A) or normal saline (Group B) in equal volume for 60 min after cardiopulmonary bypass (CPB). The cardiac output, cardiac index, stroke volume index, fractional area of contraction and systemic vascular resistance index were significantly higher in Group A than in Group B. Adrenaline (mean dose: 0.06 μg/kg•min-1) was required in seven patients from Group B but in none of the Group A patients on initial separation from CPB (P< 0.05). Of the 10 patients in Group B, five required phenylepherine to maintain the mean arterial pressure (MAP) >65 mmHg, whereas none of the Group A patients required phenylephrine for MAP regulation (P< 0.05). We conclude that Infusion of low-dose vasopressin for patients with mild to moderate left ventricular systolic dysfunction during separation from CPB is beneficial for the postoperative hemodynamic profile, reduces the catecholamine doses required and improves left ventricular systolic function.en_US
dc.identifier.citationElgebaly Ahmed Said, Sabry Mohab. Infusion of low-dose vasopressin improves left ventricular function during separation from cardiopulmonary bypass: A double-blind randomized study. Annals of Cardiac Anaesthesia. 2012 Apr; 15(2): 128-133.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139654
dc.language.isoenen_US
dc.source.urihttps://www.annals.in/article.asp?issn=0971-9784;year=2012;volume=15;issue=2;spage=128;epage=133;aulast=Elgebalyen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectleft ventricular functionen_US
dc.subjecttransesophageal echocardiographyen_US
dc.subjectvasopressinen_US
dc.subject.meshAdult
dc.subject.meshAnesthesia
dc.subject.meshBlood Pressure --drug effects
dc.subject.meshCardiac Catheterization
dc.subject.meshCardiac Output --drug effects
dc.subject.meshCardiopulmonary Bypass --methods
dc.subject.meshDouble-Blind Method
dc.subject.meshEchocardiography, Transesophageal
dc.subject.meshFemale
dc.subject.meshHemostatics --administration & dosage
dc.subject.meshHemostatics --therapeutic use
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMyocardial Contraction --drug effects
dc.subject.meshPhenylephrine --therapeutic use
dc.subject.meshStroke Volume --drug effects
dc.subject.meshVascular Resistance --drug effects
dc.subject.meshVasoconstrictor Agents --therapeutic use
dc.subject.meshVasopressins --administration & dosage
dc.subject.meshVasopressins --therapeutic use
dc.subject.meshVentricular Function, Left --drug effects
dc.titleInfusion of low-dose vasopressin improves left ventricular function during separation from cardiopulmonary bypass: A double-blind randomized study.en_US
dc.typeArticleen_US
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