Parthenium dermatitis treated with azathioprine weekly pulse doses.

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dc.contributor.authorVerma, Kaushal Ken_US
dc.contributor.authorBansal, Arikaen_US
dc.contributor.authorSethuraman, Gen_US
dc.date.accessioned2009-05-28T08:22:33Z
dc.date.available2009-05-28T08:22:33Z
dc.date.issued2006-01-17en_US
dc.description.abstractBACKGROUND: Parthenium dermatitis is a serious problem in India. Corticosteroids are the mainstay of treatment but the prolonged use of corticosteroids can cause serious side effects. Azathioprine used in daily doses has been shown to be effective. AIM: We have evaluated the effectiveness of azathioprine weekly pulse doses for the treatment of parthenium dermatitis. METHODS: Twelve patients, ten males and two females, aged between 39 and 65 years (mean +/- SD = 53.5 +/- 8.7) having air-borne contact dermatitis to Parthenium hysterophorus for 3-19 years (mean = 6.33) were included in the study. The diagnosis in each patient was confirmed by patch-testing. The severity of the disease was determined by clinical severity score (CSS) on the basis of erythema, itching, type of lesions, and areas of body involved. RESULTS: The pretreatment CSS in these patients varied from 29.7 to 55.5 (mean +/- SD: 40.40 +/- 7.95). After clinical and laboratory evaluation, the patients were treated with 300-mg azathioprine once-weekly doses for 6 months. Clinical and laboratory evaluations were repeated at weeks 1, 2, and then every 4 weeks until the end of therapy to evaluate the therapeutic response and side effects. The response was excellent (80-100% clearance of disease) in seven (58.33%) patients and good (60% clearance) in five (41.66%) patients. The post-treatment CSS decreased from the mean +/- SD of 40.4 +/- 7.95 to 10.9 +/- 8.43 (P = 0.002). There were no significant side effects of the therapy. CONCLUSIONS: In this preliminary open study, azathioprine in weekly pulse doses has been found to be effective without any serious adverse effects in the treatment of parthenium dermatitis. The cost of therapy with this regimen is reduced by 60%.en_US
dc.description.affiliationDepartment of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. prokverma@hotmail.comen_US
dc.identifier.citationVerma KK, Bansal A, Sethuraman G. Parthenium dermatitis treated with azathioprine weekly pulse doses. Indian Journal of Dermatology, Venereology and Leprology. 2006 Jan-Feb; 72(1): 24-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/52515
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAzathioprine --administration & dosageen_US
dc.subject.meshDermatitis, Contact --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulse Therapy, Drugen_US
dc.subject.meshTanacetum parthenium --adverse effectsen_US
dc.titleParthenium dermatitis treated with azathioprine weekly pulse doses.en_US
dc.typeJournal Articleen_US
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