Role of Aluminium in Alzheimer’s disease: Ultrastructural Study in Rat Hippocampus
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Date
2023-06
Journal Title
Journal ISSN
Volume Title
Publisher
IMD Research Publications
Abstract
Background: Exposure to high levels of aluminium (Al) leads to neurotoxicity. Hippocampus is one of the preferred sites of aluminium accumulation. Nevertheless, the role of Al in Alzheimer’s disease (AD) remains controversial and there is little proof directly interlinking Al to AD. Aims: The present study was undertaken to find out the occurrence of AD pathogenesis in Hippocampus under moderate aluminium exposure in rats. Materials and Methods: Adult rats were divided into control (C) and aluminium treated (E) groups having eight animal each. The rats in group E were exposed to aluminium 4.2 mg/kg body weight for three months with due approval from Institute Animal Ethics Committee. The hippocampus was processed for histopathological and electron microscopy observation. Results: Moderate Al intake produces significant reduction in the count of Pyramidal cells in hippocampus identified by shrunken cells as well as pyknosis in cell bodies. The differences between the cell numbers in all groups were found to be statistically significant (P < 0.05). Cornu Ammonis (CA) exhibited significantly reduced nissl bodies with a marked reduction in neuronal cell loss. Neurofibrillary tangle and plaques were not seen in the given dose of Al exposure. Electron microscopy from experimental group showed that the majority of neurons were disintegrating, the nuclear membrane has ruptured, and nucleoli appeared significantly distorted. The chromatin condensed and the mitochondria had disintegrated. Many vacuoles and lipofuscin sediment in cytoplasm, as compared to the control group noted. Conclusion: Present data demonstrated that moderate chronic aluminium exposure 4.2mg/kg body weight induced neurodegeneration in hippocampus but not significant for Alzheimer’s disease pathogenesis.
Description
Keywords
Aluminium, Hippocampus, Alzheimer’s Disease, Neurodegeneration, Histopathology, Electron microscopy.
Citation
Ghosh Buddhadeb, Akhtaruzzaman, Hansda Shukchand, Yadav Suman, Sharma Ravi Kant. Role of Aluminium in Alzheimer’s disease: Ultrastructural Study in Rat Hippocampus. International Journal of Anatomy and Research. 2023 Jun; 11(2): 8610-8618