The role of cadmium in induction of atherosclerosis in rabbits.

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dc.contributor.authorSubramanyam, Gen_US
dc.contributor.authorBhaskar, Men_US
dc.contributor.authorGovindappa, Sen_US
dc.date.accessioned1992-05-01en_US
dc.date.accessioned2009-05-27T04:18:15Z
dc.date.available1992-05-01en_US
dc.date.available2009-05-27T04:18:15Z
dc.date.issued1992-05-01en_US
dc.description.abstractExperiments were carried out in rabbits to determine the effects of prolonged treatment of cadmium (8 mg/kg/day) for a period of 6 months on histopathological changes and biochemical alterations of lipid profiles in various tissues compared to normal rabbits. No ECG changes were observed before and at the end of cadmium treatment. Histopathological studies of the coronary artery revealed atherosclerotic changes. Total lipids, cholesterol, free fatty acids and phospholipids were significantly increased in heart and kidney, but decreased in serum and liver. Triglyceride content was increased significantly in heart and kidney with a significant depletion in liver and serum. It is postulated that atherosclerotic changes in rabbits probably occurred through toxic effects of cadmium but the exact mechanism needs to be elucidated.en_US
dc.description.affiliationDepartment of Cardiology, S. V. Medical College, Tirupati.en_US
dc.identifier.citationSubramanyam G, Bhaskar M, Govindappa S. The role of cadmium in induction of atherosclerosis in rabbits. Indian Heart Journal. 1992 May-Jun; 44(3): 177-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/3094
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteriosclerosis --chemically induceden_US
dc.subject.meshCadmium --toxicityen_US
dc.subject.meshCadmium Chlorideen_US
dc.subject.meshCadmium Poisoning --pathologyen_US
dc.subject.meshChlorides --toxicityen_US
dc.subject.meshCoronary Artery Disease --chemically induceden_US
dc.subject.meshCoronary Vessels --pathologyen_US
dc.subject.meshKidney --pathologyen_US
dc.subject.meshLipids --blooden_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth, Vascular --pathologyen_US
dc.subject.meshRabbitsen_US
dc.titleThe role of cadmium in induction of atherosclerosis in rabbits.en_US
dc.typeJournal Articleen_US
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