Diagnostic Yield of Pneumococcal Antigen Detection in Cerebrospinal Fluid for Diagnosis of Pneumococcal Meningitis Among Children in China

Simple item page
dc.contributor.authorYong-Ping, Xieen_US
dc.contributor.authorChun-Zhen, Huaen_US
dc.contributor.authorHong-Jiao, Wangen_US
dc.contributor.authorAn-Na, Sunen_US
dc.contributor.authorJue, Shenen_US
dc.date.accessioned2020-04-23T07:45:05Z
dc.date.available2020-04-23T07:45:05Z
dc.date.issued2020-01
dc.description.abstractObjective: To determine the diagnostic accuracy of pneumococcal antigen detection indiagnosis of pneumococcal meningitis in children. Methods: Purulent meningitis wasdiagnosed according to European Society for Clinical Microbiology and Infectious Diseases(ESCMID) guideline between July 2014 and June 2016. Along with a cerebrospinal fluid(CSF) culture, pneumococcal antigen detection in cerebrospinal fluid (CSF) was performed,and further identification of pathogens was done with 16S rDNA-PCR and high-throughputsequencing. Results: CSF samples collected from 184 children (median age of 1.92 mo).CSF culture was used as the gold standard. 46 (25%) had positive results for culture and 10(5.4%) were pneumococci; 34 (18.5%) were pneumococcal antigen positive. The sensitivityand specificity of pneumococcal antigen detection were 100% (95% CI: 89.4%–100%) and86.2% (95% CI: 96.4%–99.9%), respectively. 92.3% (12/13) were confirmed by nucleic aciddetection to be pneumococci. Conclusions: Pneumococcal antigen detection in CSF hasadequate sensitivity and specificity in diagnosing pneumococcal meningitis.en_US
dc.identifier.affiliationsDivision of Infectious Diseases, Children’s Hospital, ZhejiangUniversity School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, PR China.en_US
dc.identifier.affiliationslinical Laboratory Center, Children’s Hospital, ZhejiangUniversity School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, PR China.en_US
dc.identifier.affiliationsDepartment of Neurology, Children’s Hospital, ZhejiangUniversity School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, PR China.en_US
dc.identifier.citationYong-Ping Xie, Chun-Zhen Hua, Hong-Jiao Wang, An-Na Sun, Jue Shen. Diagnostic Yield of Pneumococcal Antigen Detection in Cerebrospinal Fluid for Diagnosis of Pneumococcal Meningitis Among Children in China. Indian Pediatrics. 2020 Jan; 57(1): 39-42en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199517
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber1en_US
dc.relation.volume57en_US
dc.source.urihttps://www.indianpediatrics.net/jan2020/39.pdfen_US
dc.subjectEtiologyen_US
dc.subjectRapid diagnosisen_US
dc.subjectSensitivityen_US
dc.subjectSpecificityen_US
dc.titleDiagnostic Yield of Pneumococcal Antigen Detection in Cerebrospinal Fluid for Diagnosis of Pneumococcal Meningitis Among Children in Chinaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ip2020v57n1p39.pdf
Size:
94.19 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Pediatrics