Immunohistochemical co-expression of human papillomavirus type 16/18 transforming (E6) oncoprotein and p53 tumour suppressor gene proteins in oesophageal cancer.

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dc.contributor.authorAgarwal, S Ken_US
dc.contributor.authorChatterji, Aen_US
dc.contributor.authorBhambhani, Sen_US
dc.contributor.authorSharma, B Ken_US
dc.date.accessioned2009-05-28T11:08:06Z
dc.date.available2009-05-28T11:08:06Z
dc.date.issued1998-06-10en_US
dc.description.abstractHuman papillomaviruses have been widely implicated as important etiologic agents in various squamous cell carcinomas including oesophageal carcinoma. p53 mutant oncoprotein has also been implicated in various tumours. Immunohistochemical analysis was employed to detect the co-expression of HPV and p53 mutant protein in biopsy specimens of patients of cancer oesophagus as well as controls. This analysis revealed a significantly higher immunopositivity (63%) of E6 oncoprotein of HPV 16/18 in carcinoma of the oesophagus. Immunoexpression of E6 oncoprotein of HPV did not alter significantly the degree of differentiation of the tumour. Seventy-seven percent of cases of oesophageal carcinoma showed strong immuno-staining for mutant p53 protein. A higher percentage (89%) of tissues showed immunoexpression of mutant p53 protein in conjunction with E6 oncoprotein of HPV 16/18 indicating a selective degradation of key cellular protein of p53 having regulatory properties which in turn leads to uncontrolled cellular proliferation. Therefore, coexpression of oncoprotein E6 of HPV 16/18 and mutant p53 protein may be considered as a "high risk" factor for progression to oesophageal malignancy.en_US
dc.description.affiliationDepartment of Medicine, Maulana Azad Medical College, New Delhi, India.en_US
dc.identifier.citationAgarwal SK, Chatterji A, Bhambhani S, Sharma BK. Immunohistochemical co-expression of human papillomavirus type 16/18 transforming (E6) oncoprotein and p53 tumour suppressor gene proteins in oesophageal cancer. Indian Journal of Experimental Biology. 1998 Jun; 36(6): 559-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56288
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshDNA-Binding Proteinsen_US
dc.subject.meshEsophageal Neoplasms --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshOncogene Proteins, Viral --geneticsen_US
dc.subject.meshPapillomaviridae --geneticsen_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshTumor Suppressor Protein p53 --geneticsen_US
dc.titleImmunohistochemical co-expression of human papillomavirus type 16/18 transforming (E6) oncoprotein and p53 tumour suppressor gene proteins in oesophageal cancer.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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