Determination of shelf life of four herbal medicinal products using high-performance liquid chromatography analyses of markers and the Systat Sigmaplot software

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dc.contributor.authorKumadoh, Dorisen_US
dc.contributor.authorKwabena, Ofori Kwakyeen_US
dc.contributor.authorNoble, Kuntworbeen_US
dc.contributor.authorOfosua, Adi-Dakoen_US
dc.contributor.authorJames, Addy Appenahieren_US
dc.date.accessioned2020-10-16T08:56:34Z
dc.date.available2020-10-16T08:56:34Z
dc.date.issued2020-06
dc.description.abstractShelf life determination of herbal medicines is of paramount importance as it relates to activity of constituents of theproduct. This work sought to determine shelf life of four herbal products (Nibima, Asena, Lippia tea, and NPK 500capsules). The method involved the determination of marker content of products (three batches each) at time points(0, 3, 6, 9, 12, and 18 months) at storage temperature and humidity of 30°C ± 2°C/70% RH ± 5% RH using highperformance liquid chromatography (HPLC) analyses. Batch blending was employed for preparation of referencesamples of products. In UV analyses, λmax of 289, 291, 327, and 289 nm were obtained from spectra for (Nibima,Asena, Lippia tea, and NPK 500 capsules, respectively. A common 230 nm UV marker was observed for all theproducts. Optimized HPLC conditions were developed for products using methanol: water: 0.1%v/v acetic acidsystem with mobile phase ratios of 9:0:1 (Nibima), 7:2:1 (Asena), 8:1:1 (Lippia tea), and 90:5:5 (NPK 500 capsules).Wavelength of detection used for HPLC analyses were 283, 290, 332, and 290 nm for Nibima, Asena, Lippia tea, andNPK 500 capsules, respectively. HPLC marker content analyses with time produced shelf life of 23.14, 21.16, 62.97and 32.91 months for Nibima, Asena, Lippia tea, and NPK 500 capsules, respectively. Obtained shelf life indicatesrelative stability of products.en_US
dc.identifier.affiliationsCentre for Plant Medicine Research, Mampong Akuapem, Ghana.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghanaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghanaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Microbiology, School of Pharmacy, University of Ghana, Accra, Ghana.en_US
dc.identifier.affiliationsCentre for Plant Medicine Research, Mampong Akuapem, Ghana.en_US
dc.identifier.citationKumadoh Doris, Kwabena Ofori Kwakye, Noble Kuntworbe, Ofosua Adi-Dako, James Addy Appenahier. Determination of shelf life of four herbal medicinal products using high-performance liquid chromatography analyses of markers and the Systat Sigmaplot software. Journal of Applied Pharmaceutical Science. 2020 Jun; 2020 Jun: 072-080en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210607
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10610en_US
dc.subjectStabilityen_US
dc.subjectshelf lifeen_US
dc.subjectmarkersen_US
dc.subjectherbal productsen_US
dc.subjectUV-Vis Spectroscopyen_US
dc.subjectHPLC.en_US
dc.titleDetermination of shelf life of four herbal medicinal products using high-performance liquid chromatography analyses of markers and the Systat Sigmaplot softwareen_US
dc.typeJournal Articleen_US
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