Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats.

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dc.contributor.authorBalakumar, Mahalingam
dc.contributor.authorSaravanan, Natarajan
dc.contributor.authorPrabhu, Durai
dc.contributor.authorRegin, Bhaskaran
dc.contributor.authorReddy, G Bhanuprakash
dc.contributor.authorMohan, Viswanathan
dc.contributor.authorRema, Mohan
dc.contributor.authorBalasubramanyam, Muthuswamy
dc.date.accessioned2013-07-26T08:49:03Z
dc.date.available2013-07-26T08:49:03Z
dc.date.issued2013-01
dc.description.abstractWhile there is an emphasis on the early glycemic control for its long-term benefits in preventing microvascular complications of diabetes, the biochemical mechanisms responsible for the long-lasting effects are not clearly understood. Therefore the impact of early insulin (EI) versus late insulin (LI) treatment on diabetic sensory neuropathy and cataract in streptozotocin-induced diabetic Wistar male rats were evaluated. EI group received insulin (2.5 IU/animal, once daily) treatment from day 1 to 90 while LI group received insulin from day 60 to 90. Early insulin treatment significantly reduced the biochemical markers like glucose, triglyceride, glycated hemoglobin, thiobarbituric acid reactive substances, advanced glycation end products and ratio of reduced glutathione and oxidized glutathione in diabetic rats. The late insulin treatment failed to resist the biochemical changes in diabetic rats. Diabetic rats developed sensory neuropathy as evidenced by mechanical and thermal hyperalgesia and showed a higher incidence and severity of cataract as revealed by slit lamp examination. Early insulin treatment protected the rats from the development of neuropathy and cataract, but late insulin administration failed to do so. The results demonstrate the benefits of early glycemic control in preventing neuropathy and cataract development in diabetic rats.en_US
dc.identifier.citationBalakumar Mahalingam, Saravanan Natarajan, Prabhu Durai, Regin Bhaskaran, Reddy G Bhanuprakash, Mohan Viswanathan, Rema Mohan, Balasubramanyam Muthuswamy. Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats. Indian Journal of Experimental Biology. 2013 Jan; 51(1): 56-64.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147568
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/15277en_US
dc.subjectAdvanced glycation end productsen_US
dc.subjectHyperglycemic memoryen_US
dc.subjectLipid peroxidationen_US
dc.subjectMicrovascular complicationsen_US
dc.subject.meshAnimals
dc.subject.meshBlood Glucose --drug effects
dc.subject.meshBlood Glucose --metabolism
dc.subject.meshCataract --metabolism
dc.subject.meshDiabetes Complications --metabolism
dc.subject.meshDiabetes Mellitus, Experimental --therapy
dc.subject.meshDiabetic Neuropathies --drug therapy
dc.subject.meshDiabetic Neuropathies --prevention & control
dc.subject.meshDisease Models, Animal
dc.subject.meshGlutathione --metabolism
dc.subject.meshGlycosylation End Products, Advanced
dc.subject.meshHyperglycemia --therapy
dc.subject.meshInsulin --metabolism
dc.subject.meshLens, Crystalline --metabolism
dc.subject.meshLipid Peroxidation
dc.subject.meshMale
dc.subject.meshPain Threshold
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.titleBenefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats.en_US
dc.typeArticleen_US
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