Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.

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dc.contributor.authorBhowmick, Sen_US
dc.contributor.authorBose, Ren_US
dc.contributor.authorPal, Men_US
dc.contributor.authorPal, S Pen_US
dc.date.accessioned2009-05-28T13:56:42Z
dc.date.available2009-05-28T13:56:42Z
dc.date.issued1990-02-01en_US
dc.description.abstractN-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.en_US
dc.description.affiliationDepartment of Pharmacy, Jadavpur University, Calcutta, India.en_US
dc.identifier.citationBhowmick S, Bose R, Pal M, Pal SP. Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent. Indian Journal of Experimental Biology. 1990 Feb; 28(2): 190-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60068
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.mesh3-Mercaptopropionic Acid --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Ulcer Agentsen_US
dc.subject.meshBicuculline --analogs & derivativesen_US
dc.subject.meshCimetidine --therapeutic useen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshStomach Ulcer --drug therapyen_US
dc.subject.meshValproic Acid --therapeutic useen_US
dc.subject.meshgamma-Aminobutyric Acid --analogs & derivativesen_US
dc.titleAntiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.en_US
dc.typeJournal Articleen_US
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