Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology.

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dc.contributor.authorAgarwal, Ashoken_US
dc.contributor.authorPrabakaran, Sushil Aen_US
dc.date.accessioned2009-05-28T13:29:51Z
dc.date.available2009-05-28T13:29:51Z
dc.date.issued2005-11-01en_US
dc.description128 references.en_US
dc.description.abstractNumerous factors influence male fertility. Among these factors is oxidative stress (OS), which has elicited an enormous interest in researchers in recent period. Reactive oxygen species (ROS) are continuously produced by various metabolic and physiologic processes. OS occurs when the delicate balance between the production of ROS and the inherent antioxidant capacity of the organism is distorted. Spermatozoa are particularly sensitive to ROS as their plasma membrane contains polyunsaturated fatty acids (PUFA), which oxidizes easily. They also lack cytoplasm to generate a robust preventive and repair mechanism against ROS. The transition metal ions that are found in the body have a catalytic effect in the generation of ROS. Lifestyle behaviours such as smoking and alcohol use and environmental pollution further enhance the generation of ROS and thus, cause destructive effects on various cellular organelles like mitochondria, sperm DNA etc. This article analyzes the detrimental effects of OS on male fertility, measurement of OS and effective ways to decrease or eliminate them completely. We have also provided information on oxidative stress in other systems of the body, which may be applied to future research in the field of reproductive biology.en_US
dc.description.affiliationCenter for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, Ohio, 44195, USA. Agarwaa@ccf.orgen_US
dc.identifier.citationAgarwal A, Prabakaran SA. Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology. Indian Journal of Experimental Biology. 2005 Nov; 43(11): 963-74en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59485
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --chemistryen_US
dc.subject.meshCytochromes c --metabolismen_US
dc.subject.meshDNA --metabolismen_US
dc.subject.meshFatty Acids, Unsaturated --metabolismen_US
dc.subject.meshFertilityen_US
dc.subject.meshHumansen_US
dc.subject.meshIndicators and Reagents --pharmacologyen_US
dc.subject.meshInfertility, Male --pathologyen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Chemicalen_US
dc.subject.meshNitroblue Tetrazolium --pharmacologyen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshReactive Oxygen Speciesen_US
dc.subject.meshSemen --metabolismen_US
dc.subject.meshSmokingen_US
dc.subject.meshSpermatozoa --metabolismen_US
dc.subject.meshThiobarbituric Acid Reactive Substances --chemistryen_US
dc.titleMechanism, measurement, and prevention of oxidative stress in male reproductive physiology.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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