Effect of nitrendipine, nimodipine and nisoldipine on experimentally induced myocardial infarction in rats.

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dc.contributor.authorKaur, A Hen_US
dc.contributor.authorSingh, Jen_US
dc.contributor.authorSrivastava, R Ken_US
dc.contributor.authorMathur, S Ken_US
dc.date.accessioned2009-05-28T14:54:35Z
dc.date.available2009-05-28T14:54:35Z
dc.date.issued1995-06-01en_US
dc.description.abstractCardiac necrosis was produced in rats by administering isoproterenol sulphate (85 mg/kg, sc for 4 days). The myocardial damage was proved by observing the elevated levels of serum aspartate aminotransferase, ++alanine aminotransferase and lactate dehydrogenase and the changes were confirmed by his topathology. Nitrendipine, nimodipine and nisoldipine (10 mg/kg, ip) significantly reduced the elevated levels of these enzymes. The average degree of cardiac necrosis in these rats when observed microscopically and histologically was also found to be significantly reduced on pretreatment with these drugs. Nisoldipine was more effective in preventing cardiac necrosis as compared to nitrendipine and nimodipine.en_US
dc.description.affiliationDepartment of Pharmacology & Pathology, Medical College, Rohtak, India.en_US
dc.identifier.citationKaur AH, Singh J, Srivastava RK, Mathur SK. Effect of nitrendipine, nimodipine and nisoldipine on experimentally induced myocardial infarction in rats. Indian Journal of Experimental Biology. 1995 Jun; 33(6): 420-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61312
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspartate Aminotransferases --blooden_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshIsoproterenol --toxicityen_US
dc.subject.meshL-Lactate Dehydrogenase --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction --drug therapyen_US
dc.subject.meshMyocardium --pathologyen_US
dc.subject.meshNimodipine --pharmacologyen_US
dc.subject.meshNisoldipine --pharmacologyen_US
dc.subject.meshNitrendipine --pharmacologyen_US
dc.subject.meshRatsen_US
dc.titleEffect of nitrendipine, nimodipine and nisoldipine on experimentally induced myocardial infarction in rats.en_US
dc.typeJournal Articleen_US
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