The Development of Feed Supplement Effervescent Tablets for Poultry
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2010-03-14
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Isan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน
Abstract
The objective of this research was to develop feed supplement effervescent tablets for poultry. The multivitamins are more stable in the solid dosage form (tablets) and their use is easy because it is dissolved before feeding. In this study, the effect of type and quantity of binder, lubricant, solubilizing enhancer and filler were investigated. Citric acid, tartaric acid and sodium bicarbonate (NaHCO₃) in the ratio of 1:2:3.4 were selected as effervescent base. The physico-chemical properties of the tablets were assessed according to USP29 and BP 2002. The vitamin C content was also measured. The optimum formula for multivitamins effervescent tablets was identified as 50.50% multivitamin blend, 2.5% PVP K30 (added as 30% solution in 95% ethanol), 9% corn starch, 30% effervescent base, 3% tween 80, and 5% PEG 6000. The effervescent tablets were prepared by the wet granulation method. The finished products were yellow, round, flat face tablets with typical vitamin like odor. The uniformity of weight and content, % friability, and disintegration time met the requirements of standard Pharmacopoeias.
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Isan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน; Volume 5 No.3 September-December 2009; 228-234