Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet.

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dc.contributor.authorGuido, Sen_US
dc.contributor.authorJoseph, Ten_US
dc.date.accessioned2009-05-28T14:00:11Z
dc.date.available2009-05-28T14:00:11Z
dc.date.issued1992-04-01en_US
dc.description.abstractDifferent classes of calcium antagonists, viz. verapamil (diphenylalkylamine), diltiazem (benzothiazepine), nifedipine, felodipine and nimodipine (dihydropyridines), were examined for their effects on lipid profile in rats. Clofibrate was the reference standard. Clofibrate significantly prevented the rise of serum triglycerides and total cholesterol produced by high fat diet and raised antiatherogenic index to 1.6 times than that of high fat diet controls. Of the calcium antagonists studied, felodipine was most effective in preventing the rise of serum triglycerides and total cholesterol in high fat diet fed rats. Felodipine's antiatherogenic index was very high (886%)--much more than that of clofibrate (303%). Diltiazem and nimodipine which also significantly prevented the rise in triglycerides and total cholesterol produced by high fat diet had a moderately beneficial antiatherogenic index similar to that of clofibrate. Though verapamil and nifedipine slightly increased the triglyceride levels, total cholesterol levels were reduced only by verapamil and not by nifedipine. Despite this both these drugs moderately raised antiatherogenic index similar to clofibrate.en_US
dc.description.affiliationDepartment of Pharmacology, St. John's Medical College, Bangalore, India.en_US
dc.identifier.citationGuido S, Joseph T. Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet. Indian Journal of Experimental Biology. 1992 Apr; 30(4): 292-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60143
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood --drug effectsen_US
dc.subject.meshCalcium --antagonists & inhibitorsen_US
dc.subject.meshClofibrate --pharmacologyen_US
dc.subject.meshDietary Fats --administration & dosageen_US
dc.subject.meshDiltiazem --pharmacologyen_US
dc.subject.meshFelodipine --pharmacologyen_US
dc.subject.meshLipids --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshNifedipine --pharmacologyen_US
dc.subject.meshNimodipine --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshVerapamil --pharmacologyen_US
dc.titleEffect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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