Serum Fucosylation Changes in Oral Cancer and Potentially Malignant Disorders

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dc.contributor.authorS, Madhuraen_US
dc.contributor.authorM.B, Radhikaen_US
dc.contributor.authorNadaf, Afreenen_US
dc.contributor.authorM, Soumyaen_US
dc.contributor.authorM, Sudhakaraen_US
dc.contributor.authorK, Paremalaen_US
dc.date.accessioned2020-09-24T07:26:50Z
dc.date.available2020-09-24T07:26:50Z
dc.date.issued2020-03
dc.description.abstractBackground: Cellular glycosylation changes are associatedwith different types of neoplastic transformation. Fucose is adeoxyhexose sugar that the body requires for optimal functionsof cell to cell communications and which plays a role in severalbiological events. Fucose has been considered to play asignificant role in cancer and its spread. Alpha L Fucosidase(ALF) is an exoglycosidase involved in the hydrolyticdegradation of fucose containing components of glycoproteins,glycolipids and oligosaccharides. The significance of thisenzyme in human catabolism is implied by geneticneurovisceral storage disease. Altered levels of ALF has beenreported in the plasma/serum of patients with oral cancer.Aims: To investigate the clinical usefulness of serum fucoseand α-L-fucosidase in diagnosing oral pre-cancer and cancerand study the variations of the levels of both metabolites innormal, precancerous and cancerous conditions (Squamouscell carcinoma).Methodology: The study group comprised of 87 samples of(age range: 20-70 years): control samples – healthy individualswithout any systemic illness (n =20), clinically andhistopathologically diagnosed cases of leukoplakia (n=16) andoral submucous fibrosis (n=16) and oral squamous cellcarcinoma (n=35) respectively. 2ml blood was collected byvenipuncture from every subject after informed consent, serumwas separated and checked for fucose and fucosidase byspectrophotometric analysis.Results: The Normal value range of fucose is 8.3 to 9.5 mg/ dland that of fucosidase is 22.8 ± 7.1 U/L. There is an increasein the value range of fucose and fucosidase in the tissues ofpotentially malignant disorders and Squamous cell Carcinoma.en_US
dc.identifier.affiliationsMDS Oral Pathology, Honorary Dental surgeon, Satya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsMDS Oral Pathology, Professor and HOD, Department of Oral and Maxillofacial Pathology Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsMDS Oral Pathology, Former Lecturer, Department of Oral Pathology, Government Dental College and Hospital, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsMDS Oral Pathology, Reader, Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsMDS Oral Pathology, Assistant Professor, Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationS Madhura, M.B Radhika, Nadaf Afreen, M Soumya, M Sudhakara, K Paremala. Serum Fucosylation Changes in Oral Cancer and Potentially Malignant Disorders. International Journal of Medical Research Professionals. 2020 Mar; 6(2): 112-117en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203594
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org//10..21276/ijmrp.2020.6.2.026en_US
dc.subjectOral Squamous Cell Carcinoma (OSCC)en_US
dc.subjectPotentially Malignant Disorders (PMDs)en_US
dc.subjectSerum Fucoseen_US
dc.subjectSerum Alpha- L- fucosidase.en_US
dc.titleSerum Fucosylation Changes in Oral Cancer and Potentially Malignant Disordersen_US
dc.typeJournal Articleen_US
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