Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats.

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dc.contributor.authorTamano, Seikoen_US
dc.contributor.authorSekine, Kazunorien_US
dc.contributor.authorTakase, Mitsunorien_US
dc.contributor.authorYamauchi, Kojien_US
dc.contributor.authorIigo, Masaakien_US
dc.contributor.authorTsuda, Hiroyukien_US
dc.date.accessioned2009-05-27T17:37:18Z
dc.date.available2009-05-27T17:37:18Z
dc.date.issued2008-04-21en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractStudies were undertaken to determine whether bovine lactoferrin (bLF) and related compounds, shown to prevent carcinogenesis in the colon and other organs in rats, have any toxic effects in long-term feeding studies. In experiment I, male F344/DuCrj rats received a basal diet containing 0.2% bLF for 40 weeks. No adverse findings were noted, furthermore, serum triglyceride level was significantly decreased to 72% of the control level, suggesting preventive effects against the metabolic syndrome. In experiment II, male and female F344/DuCrj rats were fed a basal diet containing 0.02, 0.2, 2.0 and 5.0% bLF, 2.0% bLF hydrolysate (bLF-H) or 0.1% lactoferricin (LFcin), a peptide derived from bLF, for 60 weeks in males and 65 weeks in females. No toxicological effects, including carcinogenicity, were evident in either sex. The results of the studies provide subjective support for safety of clinical studies of bLF for supplement use.en_US
dc.description.affiliationDIMS Institute of Medical Science, Inc., 64 Goura, Nishiazai, Azai-cho, Ichinomiya, Aichi 491-0113, Japan.en_US
dc.identifier.citationTamano S, Sekine K, Takase M, Yamauchi K, Iigo M, Tsuda H. Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. Asian Pacific Journal of Cancer Prevention. 2008 Apr-Jun; 9(2): 313-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37536
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAnimal Feeden_US
dc.subject.meshAnimalsen_US
dc.subject.meshCattleen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshLactoferrin --toxicityen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasms, Experimental --chemically induceden_US
dc.subject.meshNo-Observed-Adverse-Effect Levelen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred F344en_US
dc.subject.meshTriglycerides --blooden_US
dc.titleLack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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