Can positron emission tomography-computed tomography predict response in locally advanced rectal cancer patients treated with induction folinic acid and 5-florouracil.

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dc.contributor.authorGunduz, S
dc.contributor.authorCoşkun, H S
dc.contributor.authorArslan, D
dc.contributor.authorGoksu, S S
dc.contributor.authorTatli, A M
dc.contributor.authorUysal, M
dc.contributor.authorOzdogan, M
dc.contributor.authorSavas, B
dc.date.accessioned2014-12-30T06:30:10Z
dc.date.available2014-12-30T06:30:10Z
dc.date.issued2014-04
dc.description.abstractOBJECTIVE: The aim of this study was to determine the pathological complete response rates in a group of locally advanced rectal cancer patients who underwent chemoradiotherapy (CRT) after treatment with induction folinic acid and 5‑florouracil (FOLFOX) chemotherapy and the relationship between the complete response and positron emission tomography‑computed tomography (PET‑CT). MATERIALS AND METHODS: The files of 239 patients who were diagnosed with rectal cancer between January 2008 and January 2012 were evaluated retrospectively. Of these, there were 24 locally advanced rectal cancer patients who met the following criteria: They were administered CRT after receiving four courses induction oxaliplatin, FOLFOX and they underwent PET‑CT for staging and for the evaluation of their response to FOLFOX treatment. Of these 24 patients, 20 operable patients were included in the study. RESULTS: The pathological complete response was obtained in seven patients (35%) who were operated on and then given induction four courses FOLFOX chemotherapy and CRT. We determined that age, gender, clinical stage at diagnosis and PET‑CT before and after induction chemotherapy were not predictive of the pathological complete response to tumor fluorodeoxyglucose uptake activity. CONCLUSION: The rates of pathological complete response were increased in locally advanced rectal cancer patients who underwent short‑term induction chemotherapy. Although the PET‑CT has retained its importance in predicting pathological complete response, there is still a need for studies with a larger number of patients and long‑term follow‑ups.en_US
dc.identifier.citationGunduz S, Coşkun H S, Arslan D, Goksu S S, Tatli A M, Uysal M, Ozdogan M, Savas B. Can positron emission tomography-computed tomography predict response in locally advanced rectal cancer patients treated with induction folinic acid and 5-florouracil. Indian Journal of Cancer. 2014 Apr-Jun; 51(2): 138-141.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154315
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2014;volume=51;issue=2;spage=138;epage=141;aulast=Gunduzen_US
dc.subjectFolinic acid and 5‑florouracilen_US
dc.subjectinduction chemotherapyen_US
dc.subjectpathological complete responseen_US
dc.subjectpositron emission tomography‑computed tomographyen_US
dc.subjectrectal canceren_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic use
dc.subject.meshChemotherapy
dc.subject.meshFemale
dc.subject.meshFluorouracil --therapeutic use
dc.subject.meshInduction Chemotherapy --methods
dc.subject.meshLeucovorin --therapeutic use
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMultimodal Imaging
dc.subject.meshOrganoplatinum Compound --therapeutic use
dc.subject.meshPosition-Emission Tomography
dc.subject.meshRectal Neoplasms --drug therpy
dc.subject.meshRectal Neoplasms --pathology
dc.subject.meshRectal Neoplasms --radiotherapy
dc.subject.meshRetrospective Studies
dc.subject.meshTreatment Outcome
dc.subject.otherHumans
dc.titleCan positron emission tomography-computed tomography predict response in locally advanced rectal cancer patients treated with induction folinic acid and 5-florouracil.en_US
dc.typeArticleen_US
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