Is seroprevalence of HTLV-I/II among blood donors in India relevant?

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dc.contributor.authorKumar, Harshen_US
dc.contributor.authorGupta, P Ken_US
dc.date.accessioned2006-10-23en_US
dc.date.accessioned2009-05-29T11:05:41Z
dc.date.available2006-10-23en_US
dc.date.available2009-05-29T11:05:41Z
dc.date.issued2006-10-23en_US
dc.description.abstractHuman T-cell lymphotropic virus type I/II (HTLV-I/II) is associated with certain hematologic and neurologic disorders. Seroprevalence studies demonstrate that the distribution of HTLV-I/II is heterogeneous worldwide and not specific to one region. Because blood is one of the major routes of transmission of the virus, blood banks of several countries routinely screen all blood donations for HTLV-I/II. The aim of the present study was to assess the seroprevalence rate of HTLV-I/II antibodies among Indian blood donors and to confirm the positive rates by polymerase chain reaction (PCR). Between Jan 2004 to May 2005, consecutive blood samples of 10,000 blood donors were collected at the blood bank of Armed Forces Medical College, Pune. The samples were screened for HTLV-I/II by enzyme-linked immunosorbent assay (ELISA) method. Screening resulted in 18 (0.18%) positive samples, of which 14 (77.8%) samples were also positive by PCR. The prevalence of HTLV-I/II carriers in India seems to be negligible and is not a major public health hazard. Hence, routine screening of Indian blood donors for antibody to HTLV-I/II is not warranted due to its low prevalence in India.en_US
dc.description.affiliationDepartment of Transfusion Medicine, Armed Forces Medical College, Pune 411 040.en_US
dc.identifier.citationKumar H, Gupta PK. Is seroprevalence of HTLV-I/II among blood donors in India relevant? Indian Journal of Pathology & Microbiology. 2006 Oct; 49(4): 532-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73143
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshDNA, Viral --analysisen_US
dc.subject.meshHTLV-I Antibodies --blooden_US
dc.subject.meshHTLV-I Infections --epidemiologyen_US
dc.subject.meshHTLV-II Antibodies --blooden_US
dc.subject.meshHTLV-II Infections --epidemiologyen_US
dc.subject.meshHuman T-lymphotropic virus 1 --geneticsen_US
dc.subject.meshHuman T-lymphotropic virus 2 --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshPolymerase Chain Reaction --methodsen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.titleIs seroprevalence of HTLV-I/II among blood donors in India relevant?en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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