Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
dc.contributor.author | Rajalingam, R | en_US |
dc.contributor.author | Mehra, N K | en_US |
dc.contributor.author | Singal, D P | en_US |
dc.date.accessioned | 2009-05-28T13:20:40Z | |
dc.date.available | 2009-05-28T13:20:40Z | |
dc.date.issued | 2000-07-24 | en_US |
dc.description.abstract | Heat shock proteins (HSP) act as immunological target structures either by themselves because of an unusual expression pattern, or they are carrier proteins for immunogenic peptides. A three-allele polymorphism of HSP70-1 promoter region was analysed in random patients with pulmonary tuberculosis (PTB), or with tuberculoid (TT) leprosy and healthy controls from North India. HSP70-1A and HSP70-1C occurred more frequently (> 60%) while HSP70-1B occurred infrequently in this population. Only HSP70-1A allele was significantly increased in TT leprosy as compared to healthy controls (91.8% Vs 71.1%, Pc < 0.03, RR = 4.58). Although a strong association of HLA-DR15 was observed with both of these patient groups in earlier studies, no correlation was found between HSP70-1 promoter alleles with any of the HLA allotypes. Amongst six possible genotype combinations of HSP70-1 promoter allele, only four (A/A, A/B, A/C, C/C) were encountered in Asian Indians. A significant increase of HSP70-1 A/C genotype was observed among DR15 negative PTB patients as compared to DR15 negative controls (87.5% Vs 35.7%, X2 = 8.6, Pc < 0.02) giving highest relative risk of 12.6. These findings suggest that HSP70-1 genes may play a secondary role to HLA-DR in governing susceptibility to mycobacterial infectious diseases. | en_US |
dc.description.affiliation | Department of Histocompatibility and Immunogenetics, All India Institute of Medical Sciences, New Delhi 110 029, India. lingam@cmgm.stanford.edu | en_US |
dc.identifier.citation | Rajalingam R, Mehra NK, Singal DP. Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Indian Journal of Experimental Biology. 2000 Jul; 38(7): 658-62 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/59284 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.asp | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Base Sequence | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | DNA Primers --genetics | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | HLA Antigens --genetics | en_US |
dc.subject.mesh | HSP70 Heat-Shock Proteins --genetics | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | India | en_US |
dc.subject.mesh | Leprosy, Tuberculoid --genetics | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Polymorphism, Genetic | en_US |
dc.subject.mesh | Promoter Regions, Genetic | en_US |
dc.subject.mesh | Tuberculosis, Pulmonary --genetics | en_US |
dc.title | Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. | en_US |
dc.type | Journal Article | en_US |
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