Synthesis, DNA cleavage and antimicrobial activity of 4-thiazolidinones-benzothiazole conjugates.

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dc.contributor.authorSingh, Meenakshi
dc.contributor.authorGangwar, Mayank
dc.contributor.authorNath, Gopal
dc.contributor.authorSingh, Sushil K
dc.date.accessioned2014-12-12T09:52:55Z
dc.date.available2014-12-12T09:52:55Z
dc.date.issued2014-11
dc.description.abstractAntimicrobial screening of several novel 4-thiazolidinones with benzothiazole moiety has been performed. These compounds were evaluated for antimicrobial activity against a panel of bacterial and fungal strains. The strains were treated with these benzothiazole derivatives at varying concentrations, and MIC’s were calculated. Structures of these compounds have been determined by spectroscopic studies viz., FT-IR, 1H NMR, 13C NMR and elemental analysis. Significant antimicrobial activity was observed for some members of the series, and compounds viz. 3-(4-(benzo[d]thiazol-2-yl) phenyl)-2-(4-methoxyphenyl)thiazolidin-4-one and 3-(4-(benzo[d]thiazol-2-yl)phenyl)-2-(4-hydroxy phenyl)thiazolidin-4-one were found to be the most active against E.coli and C.albicans with MIC values in the range of 15.6–125 μg/ml. Preliminary study of the structure–activity relationship revealed that electron donating groups associated with thiazolidine bearing benzothiazole rings had a great effect on the antimicrobial activity of these compounds and contributes positively for the action. DNA cleavage experiments gave valuable hints with supporting evidence for describing the mechanism of action and hence showed a good correlation between their calculated MIC’s and its lethality.en_US
dc.identifier.citationSingh Meenakshi, Gangwar Mayank, Nath Gopal, Singh Sushil K. Synthesis, DNA cleavage and antimicrobial activity of 4-thiazolidinones-benzothiazole conjugates. Indian Journal of Experimental Biology. 2014 Nov; 52(11): 1062-1070.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153788
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/29747en_US
dc.subjectBenzothiazolesen_US
dc.subject4-thiazolidinonesen_US
dc.subjectDNA cleavageen_US
dc.subjectMICen_US
dc.subject.meshAnti-Bacterial Agents --chemical synthesis
dc.subject.meshAnti-Bacterial Agents --chemistry
dc.subject.meshAnti-Bacterial Agents --pharmacology
dc.subject.meshAntifungal Agents --chemical synthesis
dc.subject.meshAntifungal Agents --chemistry
dc.subject.meshAntifungal Agents --pharmacology
dc.subject.meshBenzothiazoles --chemical synthesis
dc.subject.meshBenzothiazoles --chemistry
dc.subject.meshBenzothiazoles --pharmacology
dc.subject.meshCandida --drug effects
dc.subject.meshDNA, Bacterial --drug effects
dc.subject.meshDNA, Circular --drug effects
dc.subject.meshDisk Diffusion Antimicrobial Tests
dc.subject.meshDrug Evaluation, Preclinical
dc.subject.meshElectrophoresis, Agar Gel
dc.subject.meshFree Radical Scavengers --pharmacology
dc.subject.meshGram-Negative Bacteria --drug effects
dc.subject.meshGram-Positive Bacteria --drug effects
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMolecular Structure
dc.subject.meshThiazolidines --chemical synthesis
dc.subject.meshThiazolidines --chemistry
dc.subject.meshThiazolidines --pharmacology
dc.titleSynthesis, DNA cleavage and antimicrobial activity of 4-thiazolidinones-benzothiazole conjugates.en_US
dc.typeArticleen_US
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