Lead acetate induced contraction in rat tracheal smooth muscle is independent of epithelium.

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dc.contributor.authorGupta, Navinen_US
dc.contributor.authorFahim, Mohammaden_US
dc.date.accessioned2007-01-20en_US
dc.date.accessioned2009-06-01T05:22:07Z
dc.date.available2007-01-20en_US
dc.date.available2009-06-01T05:22:07Z
dc.date.issued2007-01-20en_US
dc.description.abstractAirways are the primary target of lead exposure from atmospheric pollution, its effect on airway smooth muscle and their responsiveness to bronchoactive agents is not clearly understood. In the present investigation the effect of lead on the isolated airway smooth muscle activity was studied in organ bath set-up. Further the involvement of airway epithelium was examined and the responsiveness of airway smooth muscle to adenosine, acetylcholine (bronchoconstrictors) and isoproterenol (bronchodilator) was also investigated. Lead in concentration of 10(-12) M to 10(-4) M produced concentration-dependant contractile response in rat tracheal rings. Acetylcholine and adenosine induced concentration-dependent contractile response was slightly inhibited after lead exposure. The relaxant response to isoproterenol was also inhibited in lead exposed tissues. Epithelium removal did not significantly change the contractile response to lead suggesting that the lead induced contraction of airway smooth muscle is epithelium independent.en_US
dc.description.affiliationDepartment of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi.en_US
dc.identifier.citationGupta N, Fahim M. Lead acetate induced contraction in rat tracheal smooth muscle is independent of epithelium. Indian Journal of Physiology and Pharmacology. 2007 Jan-Mar; 51(1): 49-54en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106558
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcetylcholine --pharmacologyen_US
dc.subject.meshAdenosine --pharmacologyen_US
dc.subject.meshAdrenergic beta-Agonists --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchodilator Agents --pharmacologyen_US
dc.subject.meshCholinergic Agents --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEpithelium --drug effectsen_US
dc.subject.meshIsoproterenol --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction --drug effectsen_US
dc.subject.meshMuscle Relaxation --drug effectsen_US
dc.subject.meshMuscle, Smooth --drug effectsen_US
dc.subject.meshOrganometallic Compounds --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSympathomimetics --pharmacologyen_US
dc.subject.meshTrachea --drug effectsen_US
dc.subject.meshVasodilator Agents --pharmacologyen_US
dc.titleLead acetate induced contraction in rat tracheal smooth muscle is independent of epithelium.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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