Design and characterization of intra-oral fast dissolving tablets containing diacerein-solid dispersion

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dc.contributor.authorHasan, Azzaen_US
dc.contributor.authorRamadan, Abd El hakimen_US
dc.contributor.authorElghany, Mahmoud Abden_US
dc.contributor.authorSabry, Shereenen_US
dc.date.accessioned2020-10-16T08:56:33Z
dc.date.available2020-10-16T08:56:33Z
dc.date.issued2020-06
dc.description.abstractDiacerein (Diacetylrhein, DCN) is anthraquinone derivatives used in the curing of osteoarthritis, but its usage isrestricted due to its very poor solubility and wettability which result in bioavailability variation. The objective ofthis work was to design fast dissolving tablets (FDTs) of DCN solid dispersion. Solid dispersions (SDs) and physicalmixtures (PMs) were prepared with PEG4000, Polyvinylpyrolidone K25 (PVPK25), and Sorbitol. SD formationincreased the dissolution rate of DCN compared to PM; this demonstrates that the improvement of dissolution ratewith SD can be due to physical change in drug crystal which was confirmed by thermal analysis. SD with Sorbitol wasselected for the preparations of FDTs. Seven formulations were prepared by direct compression method using differentconcentrations of crospovidone (CP) as superdisintegrant and camphor as subliming agent. Pre- and post-compressionevaluation were carried for powder blend and the prepared FDTs, respectively. F7 (composed of 120 mg CP, 45 mgcamphor, 200 mg SD containing 50 mg DCN, 7.5 mg aspartame, 2.5 mg menthol, 2.5 mg Magnesium stearate, and22.5 mg lactose) showed the shortest disintegration time and the highest dissolution rate and it was selected for furtherinvestigation. Kinetic studies of the in vitro release results showed that F7 followed first-order kinetics. Stabilitystudies conducted for formula F7 showed good stability upon storage at 30oC/75% RH and 40oC/75% RH for 12 weeks.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypten_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Port Said University, Port Said, Egypten_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypten_US
dc.identifier.affiliationsDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypten_US
dc.identifier.citationHasan Azza, Ramadan Abd El hakim, Elghany Mahmoud Abd, Sabry Shereen. Design and characterization of intra-oral fast dissolving tablets containing diacerein-solid dispersion. Journal of Applied Pharmaceutical Science. 2020 Jun; 2020 Jun: 044-053en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210604
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10607en_US
dc.subjectDiacereinen_US
dc.subjectsolid dispersionen_US
dc.subjectpolyethylene glycolen_US
dc.subjectpolyvinylpyrolidoneen_US
dc.subjectsorbitolen_US
dc.subjectfast dissolving tablets.en_US
dc.titleDesign and characterization of intra-oral fast dissolving tablets containing diacerein-solid dispersionen_US
dc.typeJournal Articleen_US
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