Preparation of a potent anti-scorpion-venom-serum against the venom of red scorpion (Buthus tamalus).

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dc.contributor.authorKankonkar, R Cen_US
dc.contributor.authorKulkurni, D Gen_US
dc.contributor.authorHulikavi, C Ben_US
dc.date.accessioned1998-10-07en_US
dc.date.accessioned2009-06-02T13:35:10Z
dc.date.available1998-10-07en_US
dc.date.available2009-06-02T13:35:10Z
dc.date.issued1998-10-07en_US
dc.description.abstractA number of children and adults, especially pregnant women succumb to the sting by red Scorpion (Buthus tamalus) in Konkan region--particularly on the coastal line. No specific antiserum or any other antidote is available to treat a victim of scorpion bite and hence the need to prepare a potent antiserum. Red Scorpion (B. tamalus) venom is a mixture of a number of protein moieties and neurotoxins of low molecular weight. Therefore, the venom is poor in antigenic composition and it is difficult to get antibodies specific to neutralise lethal factor/factors. Using Bentonite as an adjuvant and extending the period of immunization a potent antiserum has been prepared capable of neutralising the lethal factor/factors. In vivo testing carried out in albino mice, guinea pigs, dogs and langurs confirms this finding and shows that the antiserum is quite effective in neutralising the scorpion venom to save the life of envenomated animals.en_US
dc.description.affiliationAnti Scorpion-Venom-Serum Project, Haffkine Biopharmaceutical Corporation Limited, Mumbai.en_US
dc.identifier.citationKankonkar RC, Kulkurni DG, Hulikavi CB. Preparation of a potent anti-scorpion-venom-serum against the venom of red scorpion (Buthus tamalus). Journal of Postgraduate Medicine. 1998 Oct-Dec; 44(4): 85-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/117701
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntivenins --therapeutic useen_US
dc.subject.meshArachnidism --therapyen_US
dc.subject.meshChilden_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization, Passive --methodsen_US
dc.subject.meshMiceen_US
dc.subject.meshMyocarditis --prevention & controlen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPulmonary Edema --prevention & controlen_US
dc.subject.meshScorpion Venoms --antagonists & inhibitorsen_US
dc.subject.meshScorpionsen_US
dc.titlePreparation of a potent anti-scorpion-venom-serum against the venom of red scorpion (Buthus tamalus).en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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