Cellular accumulation and biological activity of hematoporphyrin derivative(L) in comparison with photofrin II.

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dc.contributor.authorKhanum, Fen_US
dc.contributor.authorJain, Ven_US
dc.date.accessioned2009-05-28T12:31:18Z
dc.date.available2009-05-28T12:31:18Z
dc.date.issued1997-04-01en_US
dc.description.abstractHematoporphyrin derivative, a drug used in the photodynamic therapy of solid tumours was synthesized in the laboratory and was called Hpd(L). Physico-chemical and biological properties of this drug have been compared with Photofrin II, the commercially available drug. Both Hpd(L) and Photofrin II possess similar properties qualitatively. Quantitatively, Hpd(L) was half as active as Photofrin II in its efficacy in causing photodynamic cytotoxicity or in the optical densities at the absorption peaks. These differences could be due to the differences in the compositions. Hpd(L) is a non-purified complex mixture of a number of porphyrin derivatives whereas Photofrin II is a relatively purer compound consisting of di- and tri-hematoporphyrins linked through ether or ester bonds. In vitro cellular uptake and retention of these drugs has been found to be a passive process not involving energy expenditure. pH and temperature of the incubation media have been found to profoundly influence these processes, while a complex relation seems to exist between physiological state of a cell and accumulation of these photosensitizers.en_US
dc.description.affiliationDepartment of Biocybernetics, Institute of Nuclear Medicine and Allied Sciences, Lucknow Marg, Delhi, India.en_US
dc.identifier.citationKhanum F, Jain V. Cellular accumulation and biological activity of hematoporphyrin derivative(L) in comparison with photofrin II. Indian Journal of Experimental Biology. 1997 Apr; 35(4): 348-55en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58195
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimetabolites --pharmacologyen_US
dc.subject.meshBiological Transport, Active --drug effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDihematoporphyrin Ether --chemistryen_US
dc.subject.meshHematoporphyrin Derivative --chemistryen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshKineticsen_US
dc.subject.meshPhotochemotherapyen_US
dc.subject.meshPhotosensitizing Agents --chemistryen_US
dc.subject.meshTemperatureen_US
dc.titleCellular accumulation and biological activity of hematoporphyrin derivative(L) in comparison with photofrin II.en_US
dc.typeJournal Articleen_US
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