Effect of Wheatgrass (Triticum aestivum) Juice on High Density Lipoprotein (HDL) Level in Experimentally Induced Dyslipidaemic Male Long Evans Rat
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Date
2015-01
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Abstract
Background: Evidence shows that high density lipoproteins (HDLs) may exert multiple
anti-atherogenic and anti-thrombotic effects that together decrease the risk of
cardiovascular morbidity in hyperlipidaemic state. Experimental studies showed that
fresh wheatgrass (Triticum aestivum Linn.) juice exerts lipid lowering effect as well as
increases HDL-cholesterol level in rats. Objective: The present study was done to
observe the effect of wheatgrass juice on serum HDL-cholesterol on experimentally
induced dyslipidaemic rats evident by reduced HDL-cholesterol level. Materials and
method: This experimental study was carried out in the Department of Pharmacology
& Therapeutics, Dhaka Medical College, Dhaka, from July 2009 to June 2010. A total
number of 48 healthy adult male Long Evans rats, age ranging from 2-3 months, and
weighing from 140-200 grams were used for the present study. Six rats were taken in
each group of total 8 groups treated differently with 1 control group. Rats of the first 5
groups were sacrificed at 29th day and their lipid profile was measured. Rests of the rats
were sacrificed at 57th day and their lipid profile was measured. Results: Mean
HDL-cholesterol of the group of rats treated with 10 mL/kg grass juice and 1%
cholesterol diet, with 10 mL/kg grass juice and with 20 mL/kg grass juice were
significantly increased (P<0.05, P<0.05, P<0.01 respectively). The mean
HDL-cholesterol of the group treated with Atorvastatin for 28 days were also
significantly increased (P<0.001). Conclusion: The present experiment showed that
HDL-cholesterol level is increased by ingestion of wheat grass juice in experimental
animals. Therefore, it provides the initial step for demonstrating cardio-protective effect
of wheatgrass juice by increasing HDL-cholesterol level in blood in dyslipidaemic state.
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Keywords
Wheatgrass juice, dyslipidaemia, high density lipoprotein (HDL), Long Evans rat
Citation
Afroz Rokhsana Dil, Nurunnabi Abu Sadat Mohammad, Khan Md Ismail, Jahan Tuhin. Effect of Wheatgrass (Triticum aestivum) Juice on High Density Lipoprotein (HDL) Level in Experimentally Induced Dyslipidaemic Male Long Evans Rat. Delta Medical College Journal. 2015 Jan; 3(1): 18-24.