The effects of Porphyromonas gingivalis LPS and Actinobacillus actinomycetemcomitans LPS on human dendritic cells in vitro, and in a mouse model in vivo.

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dc.contributor.authorMahanonda, Rangsinien_US
dc.contributor.authorPothiraksanon, Piyawadeeen_US
dc.contributor.authorSa-Ard-Iam, Noppadolen_US
dc.contributor.authorYamazaki, Kazuhisaen_US
dc.contributor.authorSchifferle, Robert Een_US
dc.contributor.authorHirunpetcharat, Chakriten_US
dc.contributor.authorYongvanichit, Kosolen_US
dc.contributor.authorPichyangkul, Sathiten_US
dc.date.accessioned2009-05-27T17:23:45Z
dc.date.available2009-05-27T17:23:45Z
dc.date.issued2006-12-14en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractInteraction between different bacterial plaque pathogens and dendritic cells may induce different types of T helper (Th) cell response, which is critical in the pathogenesis of periodontitis. In this study we investigated the effects of lipopolysaccharide (LPS) from Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans on human monocyte-derived dendritic cells (Mo-DCs) with respect to co-stimulatory molecule expression, cytokine production and Th cell differentiation. Unlike Escherichia coli and A. actinomycetemcomitans LPS, P. gingivalis LPS induced only low levels of CD40, CD80, HLA-DR and CD83 expression on Mo-DCs. LPS from both bacteria induced considerably lower TNF-alpha and IL-10 than did E. coli LPS. LPS from all three bacteria induced only negligible IL-12 production. In a human mixed-leukocyte reaction, and in an ovalbumin-specific T cell response assay in mice, both types of LPS suppressed IFN-gamma production. In conclusion, stimulation by P. gingivalis LPS and A. actinomycetemcomitans LPS appears to bias Mo-DCs towards Th2 production.en_US
dc.description.affiliationDepartment of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. mrangsin@chula.ac.then_US
dc.identifier.citationMahanonda R, Pothiraksanon P, Sa-Ard-Iam N, Yamazaki K, Schifferle RE, Hirunpetcharat C, Yongvanichit K, Pichyangkul S. The effects of Porphyromonas gingivalis LPS and Actinobacillus actinomycetemcomitans LPS on human dendritic cells in vitro, and in a mouse model in vivo. Asian Pacific Journal of Allergy and Immunology. 2006 Dec; 24(4): 223-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37098
dc.language.isoengen_US
dc.subject.meshActinobacillus actinomycetemcomitans --chemistryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Differentiation --immunologyen_US
dc.subject.meshCell Differentiation --drug effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCoculture Techniquesen_US
dc.subject.meshCytokines --immunologyen_US
dc.subject.meshDendritic Cells --cytologyen_US
dc.subject.meshEscherichia coli --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshLipopolysaccharides --chemistryen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshModels, Immunologicalen_US
dc.subject.meshPorphyromonas gingivalis --chemistryen_US
dc.subject.meshTh2 Cells --cytologyen_US
dc.titleThe effects of Porphyromonas gingivalis LPS and Actinobacillus actinomycetemcomitans LPS on human dendritic cells in vitro, and in a mouse model in vivo.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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