Serum Cholinesterase and Liver Enzymes Activities
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Date
2011-02-07
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Bulletin of the Department of Medical Sciences - วารสารกรมวิทยาศาสตร์การแพทย์
Abstract
Serum butyrylcholinesterase activity has been al a biomarker for indentification of organophosphate poisoning. The reduction of serum butyrylcholinesterase activity is found in acute to chronic exposure cases of the pesticide. To evaluate the health impact on pesticide exposure, serum butyrylcholinesterase activity in tobacco agricultural workers as an experimental group (n=100) was to non-exposed subjects (n=80). Serum butyrylcholinesterase activity was measured using propionylthiocholine activity was measured using propionylthiocholine as substrate and performed on DataPro automatic analyzer. Liver enzymes activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were also analyzed to evaluate liver damage. Average butyrylcholinesterase activities of 5,083 U/L ranged 2,037-7,169 U/L) and 5,692 U/L (ranged 3,217-7,655 U/L) were found in experimental and control group, respectively. A comparison between groups revealed that BchE activity was significantly reduced in experimental group (P
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Bulletin of the Department of Medical Sciences - วารสารกรมวิทยาศาสตร์การแพทย์; Vol.51 No.2 April - June 2009; 144-154