Association of the Epstein-Barr viruses with Hodgkin lymphoma: an analysis of pediatric cases in Thailand.

Simple item page
dc.contributor.authorHemsrichart, Vichitraen_US
dc.contributor.authorPintong, Jarupanen_US
dc.date.accessioned2009-05-27T18:10:48Z
dc.date.available2009-05-27T18:10:48Z
dc.date.issued2005-06-09en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractAn investigation as to whether any association of pediatric HL in Thailand was likely to be EBV positive was performed on formalin-fixed paraffin embedded tissue sections using in situ hybridization for EBV encoded RNA (EBER) technique. The analysis was performed on 15 cases. They were 11 male and 4 female cases. The subtypes of HL according to WHO classification were nodular lymphocyte predominance in 1 (6.6%), nodular sclerosis in 4 (26.6%), mixed cellularity in 9 (60%) and lymphocyte depletion in 1 (6.6%). EBV encoded RNA by in situ hybridization was demonstrated in 92.8% of classic HL: 3 of 4 (75%) with nodular sclerosis; 9 of the 9 with mixed cellularity (100%) and 1 of 1 (100%) with lymphocyte depletion. Case of nodular lymphocyte predominance was negative for EBV, CD 15 CD 30 and positive for CD 20. CD 15 and CD 30 were positive in 78.6% and 85% respectively for classic HL. Our results suggest a strong association of EBV with pediatric classic HL (92.3%) particularly the mixed cellularity subtype (100%). The result confirms the male predominance in pediatric HL. Mixed cellularity is the most common subtype of HL in our series (60%).en_US
dc.description.affiliationInstitute of Pathology, Department of Medical Services, Ministry of Public Health, Bangkok 10400, Thailand.en_US
dc.identifier.citationHemsrichart V, Pintong J. Association of the Epstein-Barr viruses with Hodgkin lymphoma: an analysis of pediatric cases in Thailand. Journal of the Medical Association of Thailand. 2005 Jun; 88(6): 782-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38619
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshEpstein-Barr Virus Infections --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human --isolation & purificationen_US
dc.subject.meshHodgkin Disease --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThailanden_US
dc.titleAssociation of the Epstein-Barr viruses with Hodgkin lymphoma: an analysis of pediatric cases in Thailand.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand