Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study.

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dc.contributor.authorNirmal, S A
dc.contributor.authorBairagi, J H
dc.contributor.authorPatil, A N
dc.contributor.authorPal, S C
dc.contributor.authorUpasani, C D
dc.contributor.authorMandal, S C
dc.date.accessioned2013-02-25T04:58:58Z
dc.date.available2013-02-25T04:58:58Z
dc.date.issued2012-01
dc.description.abstractThe wood of the plant Sesbania sesban, is reported to have antinociceptive activity. To validate its folk use in the treatment of pain, wood was extracted successively with petroleum ether, chloroform, ethyl acetate, ethanol, and water to produce respective extracts. The extracts (50 and 100 mg/kg, ip) were screened for antinociceptive activity using hot plate test and acetic acid-induced writhing test in mice. Petroleum ether, chloroform, and ethyl acetate extracts showed significant and dose-dependent activity in both the tests. In order to find out the involvement of opioid receptors, effect of naloxone (1 mg/kg, sc) on the action of extracts was checked in hot plate test. Petroleum ether, chloroform, and ethyl acetate extracts showed significant and dose dependant antinociceptive activity. The antinociceptive action of the extracts was blocked by naloxone, suggesting involvement of opioid receptors in the action.en_US
dc.identifier.citationNirmal S A, Bairagi J H, Patil A N, Pal S C, Upasani C D, Mandal S C. Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study. Indian Journal of Experimental Biology. 2012 Jan; 50(1): 61-64.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145224
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/13312en_US
dc.subjectHot plate testen_US
dc.subjectNaloxoneen_US
dc.subjectSesbania sesbanen_US
dc.subjectWrithing testen_US
dc.titleAntinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study.en_US
dc.typeArticleen_US
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