Causative fungi and treatment outcome of dematiaceous fungal keratitis in North India

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dc.contributor.authorKumar, Aen_US
dc.contributor.authorKhurana, Aen_US
dc.contributor.authorSharma, Men_US
dc.contributor.authorChauhan, Len_US
dc.date.accessioned2020-04-10T02:03:49Z
dc.date.available2020-04-10T02:03:49Z
dc.date.issued2019-07
dc.description.abstractPurpose: The aim of the study is to identify risk factors, clinical characteristics, causative fungi, and treatment outcome of dematiaceous fungal keratitis in North India. Methods: Consecutive cases of culture-proven dematiaceous fungal keratitis between January 2012 and June 2017 were retrieved from the medical record department. Risk factors, clinical signs, and outcome were registered. Results: Eighty-three patients were included. Identified dematiaceous fungal organism were Curvularia sp. (n = 55/83; 66.3%), Alternaria sp. (n = 12/83; 14.5%), Ulocladium sp. (n = 5/83; 6%), Bipolaris sp. (n = 5/83; 6.1%), Scedosporium sp. (n = 3/83; 3.6%), Acremonium sp. (n = 2/83; 2.4%), and Epicoccum sp. (n = 1/83; 1.2%). Male preponderance was reported. The most common predisposing factor was corneal trauma (67.4%). In cases associated with corneal trauma due to vegetative matter, sugarcane was the most common cause. In all, 89% of the patients were more than 30 years of age. The median infiltrate size was 8 mm2. The median time of antifungal therapy was 4.2 weeks (interquartile range [IQR]: 1-25 weeks). Complications were seen in 14 (n = 14/65; 21.5%) patients. Complete resolution of dematiaceous fungal keratitis was present in 27 (n = 27/65; 41.5%) eyes. Conclusion: Curvularia sp. and Alternaria sp. were the predominant pathogenic genera causing dematiaceous fungal keratitis. Among the causative fungi, infections due to Scedosporium sp. were associated with the worst outcomes. Ulocladium sp. and Epicoccum sp. were also identified. Both the species are not reported previously as a causal organism of dematiaceous fungal keratitis from North India.en_US
dc.identifier.affiliationsDepartment of Cornea and Refractive Error, C L Gupta Eye Institute, Ram Ganga Vihar, Phase 2(Ext) Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, C L Gupta Eye Institute, Ram Ganga Vihar, Phase 2(Ext) Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Research, C L Gupta Eye Institute, Ram Ganga Vihar, Phase 2(Ext) Moradabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationKumar A, Khurana A, Sharma M, Chauhan L. Causative fungi and treatment outcome of dematiaceous fungal keratitis in North India. Indian Journal of Ophthalmology. 2019 Jul; 67(7): 1048-1053en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/197332
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber7en_US
dc.relation.volume67en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_1612_18en_US
dc.subjectAlternariaen_US
dc.subjectCurvulariaen_US
dc.subjectdematiaceous fungien_US
dc.subjectEpicoccumen_US
dc.subjectkeratitisen_US
dc.subjectUlocladiumen_US
dc.subjectUttar Pradeshen_US
dc.titleCausative fungi and treatment outcome of dematiaceous fungal keratitis in North Indiaen_US
dc.typeJournal Articleen_US
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