Dedifferentiation
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Date
2010-11-03
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Khon Kaen University Dental Journal
Abstract
Besides ethical issues, the undesired effects such as carcinogenesis are the possible problems derived from using human embryonic stem cell (ES cell). Thus to avoid the above drawbacks in tissue substitution including teeth and oral tissues on tissue engineering principle, the technique so called dedifferentiation was introduced. Adult somatic cells especially fibroblastic cells are subjected to transforming into embryonic-like stem cells by four crucial factors which are c-myc, oct3/4, sox-2 and klf-4. Such dedifferentiated cells have properties quite similar to embryonic stem cells which in possessing the capability to differentiate into many types of cells. This method could decrease the risk of utilizing embryonic stem cells and reduce the cost of stem cell therapy in the future; and may be one of the effective methods to substitute lost dental tissues Key word dedifferentiation, adult stem cells
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Khon Kaen University Dental Journal; Vo.12 No. 2 July - Dec. 2009