Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.

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dc.contributor.authorRoy, Subhadraen_US
dc.contributor.authorGhosh, Sonalien_US
dc.contributor.authorMallick, Palashen_US
dc.contributor.authorMaity, Putulen_US
dc.date.accessioned2009-05-28T16:07:44Z
dc.date.available2009-05-28T16:07:44Z
dc.date.issued2008-01-14en_US
dc.description.abstractTumor cells intensely utilize glutamine as the major source of respiratory fuel. Glutamine-analogue acivicin inhibits tumor growth and tumor-induced angiogenesis in Ehrlich ascites carcinoma. In the present study, antitumor properties of acivicin in combination with glutaminase enzyme is reported. Acivicin along with E. coli glutaminase synergistically reduced in vitro proliferation and matrigel invasion of human MCF-7 and OAW-42 cells. Effects of single and combined treatments with acivicin and glutaminase on angiogenic factors were also analyzed in these cell lines. Co-administration of the treatment agents inhibits the release of VEGF and MMP-9 by cells in culture supernatant significantly than single agent treatments. The result suggests that combination of acivicin with glutaminase may provide a better therapeutic option than either of them given separately for treating human breast and ovarian cancer. However, further studies are required to be conducted in vivo for its confirmation.en_US
dc.description.affiliationDepartment of Metabolic Regulation, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India.en_US
dc.identifier.citationRoy S, Ghosh S, Mallick P, Maity P. Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study. Indian Journal of Experimental Biology. 2008 Jan; 46(1): 22-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62843
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/4410/1/IJEB%2046%281%29%2022-26.pdfen_US
dc.subject.meshAntimetabolites, Antineoplastic --chemistryen_US
dc.subject.meshBreast Neoplasms --metabolismen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshCollagen --chemistryen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutaminase --metabolismen_US
dc.subject.meshGlutamine --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoxazoles --chemistryen_US
dc.subject.meshLaminin --chemistryen_US
dc.subject.meshMatrix Metalloproteinase 9 --metabolismen_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshOvarian Neoplasms --metabolismen_US
dc.subject.meshProteoglycans --chemistryen_US
dc.subject.meshTetrazolium Salts --pharmacologyen_US
dc.subject.meshThiazoles --pharmacologyen_US
dc.subject.meshVascular Endothelial Growth Factor A --metabolismen_US
dc.titleAcivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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