Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model.

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dc.contributor.authorSil, Rajarshi
dc.contributor.authorRay, Doel
dc.contributor.authorChakraborti, Abhay Sankar
dc.date.accessioned2013-07-30T05:53:41Z
dc.date.available2013-07-30T05:53:41Z
dc.date.issued2013-02
dc.description.abstractThis study investigates if glycyrrhizin, a constituent of licorice (Glycyrrhiza glabra) root, is able to treat the complications (insulin resistance, hyperglycemia, dyslipidemia and oxidative stress) of metabolic syndrome. Metabolic syndrome was induced in rats by feeding a fructose-enriched (60%) diet for six weeks, after which single dose of glycyrrhizin (50 mg/kg body weight) was administered intraperitoneally. Different biochemical parameters from blood were estimated during three weeks after treatment. Then the rats were sacrificed to collect skeletal muscle tissue. Glycyrrhizin reduced the enhanced levels of blood glucose, insulin and lipids in metabolic syndrome group. Increased advanced glycation end products of hemoglobin, glycohemoglobin, hemoglobin-mediated iron release and iron-mediated free radical reactions (arachidonic acid and deoxyribose degradation) in metabolic syndrome were inhibited by glycyrrhizin treatment. Reduced activities of enzymatic antioxidants (superoxide dismutase and catalase) and elevated oxidative stress markers (malonaldehyde, fructosamine, hemoglobin carbonyl content and DNA damage) in metabolic syndrome were reversed to almost normal levels by glycyrrhizin. The decreased levels of peroxisome proliferator activated receptor (PPAR) and glucose transporter 4 (GLUT4) proteins in skeletal muscle of metabolic syndrome group were elevated by glycyrrhizin, indicating improved fatty acid oxidation and glucose homeostasis.en_US
dc.identifier.citationSil Rajarshi, Ray Doel, Chakraborti Abhay Sankar. Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. Indian Journal of Experimental Biology. 2013 Feb; 51(2): 129-138.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147576
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/15935en_US
dc.subjectMetabolic syndromeen_US
dc.subjectHigh fructose dieten_US
dc.subjectGlycationen_US
dc.subjectInsulin resistanceen_US
dc.subjectPeroxisome proliferator activated receptoren_US
dc.subjectGlucose transporter 4en_US
dc.subject.meshAnimals
dc.subject.meshBiological Markers --blood
dc.subject.meshBlood Glucose --drug effects
dc.subject.meshBlood Glucose --metabolism
dc.subject.meshBody Weight --drug effects
dc.subject.meshDNA Damage
dc.subject.meshDiet
dc.subject.meshDisease Models, Animal
dc.subject.meshDyslipidemias --blood
dc.subject.meshDyslipidemias --complications
dc.subject.meshDyslipidemias --drug therapy
dc.subject.meshFree Radical Scavengers --metabolism
dc.subject.meshFructose --adverse effects
dc.subject.meshGlucose Transporter Type 4 --metabolism
dc.subject.meshGlycyrrhizic Acid --pharmacology
dc.subject.meshGlycyrrhizic Acid --therapeutic use
dc.subject.meshHemoglobins --metabolism
dc.subject.meshHyperglycemia --blood
dc.subject.meshHyperglycemia --complications
dc.subject.meshHyperglycemia --drug therapy
dc.subject.meshInsulin --blood
dc.subject.meshInsulin Resistance
dc.subject.meshLipids --blood
dc.subject.meshLymphocytes --drug effects
dc.subject.meshLymphocytes --metabolism
dc.subject.meshMale
dc.subject.meshMetabolic Syndrome X --blood
dc.subject.meshMetabolic Syndrome X --chemically induced
dc.subject.meshMetabolic Syndrome X --complications
dc.subject.meshMetabolic Syndrome X --drug therapy
dc.subject.meshMuscles --drug effects
dc.subject.meshMuscles --metabolism
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshPPAR gamma --metabolism
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshTissue Extracts
dc.titleGlycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model.en_US
dc.typeArticleen_US
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