Antidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice.

Simple item page
dc.contributor.authorNayak, Veenaen_US
dc.contributor.authorPatil, P Aen_US
dc.date.accessioned2009-05-28T11:25:23Z
dc.date.available2009-05-28T11:25:23Z
dc.date.issued2008-03-25en_US
dc.description.abstractFosinopril, ramipril and losartan significantly decreased the duration (sec) of immobility in forced swim test and were comparable to amitriptyline. The duration of immobility were significantly decreased in fosinopril, ramipril and losartan in the tail suspension test and were comparable to amitriptyline. Only losartan significantly increased the rearing number of entries, time spent (sec) in open arm and in light area in comparison to control animals. Fosinopril and ramipril and not lisinopril showed significant antidepressant activity while losartan showed a significant antidepressant and anxiolytic activity. Present findings suggest that these drugs could be better antihypertensives in hypertensive patients with comorbidity like depression or anxiety.en_US
dc.description.affiliationDepartment of Pharmacology & Pharmacotherapeutics, J.N.Medical College, Belgaum, India.en_US
dc.identifier.citationNayak V, Patil PA. Antidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice. Indian Journal of Experimental Biology. 2008 Mar; 46(3): 180-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56693
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/4450/1/IJEB%2046%283%29%20180-184.pdfen_US
dc.subject.meshAmitriptyline --pharmacologyen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntidepressive Agents --pharmacologyen_US
dc.subject.meshAntihypertensive Agents --pharmacologyen_US
dc.subject.meshFosinopril --pharmacologyen_US
dc.subject.meshLisinopril --pharmacologyen_US
dc.subject.meshLong-Term Synaptic Depression --drug effectsen_US
dc.subject.meshLosartan --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshRamipril --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleAntidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology