Effects of captopril and losartan on thermal and chemical induced pain in mice.

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dc.contributor.authorRohit,en_US
dc.contributor.authorRao, Chakradharen_US
dc.contributor.authorKrishna, Gopalaen_US
dc.date.accessioned2006-04-21en_US
dc.date.accessioned2009-06-01T07:11:35Z
dc.date.available2006-04-21en_US
dc.date.available2009-06-01T07:11:35Z
dc.date.issued2006-04-21en_US
dc.description.abstractAngiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers antagonists (ARAs) are widely used compounds in various cardiovascular disorders. ACEIs, but not ARAs, inhibit the enzyme dipeptidyl carboxypeptidase which is involved in the conversion of angiotensin I to II and degradation of kinins like bradykinin and substance P. Bradykinin and substance P are potent mediators of inflammation and pain. Hence the study was undertaken to evaluate the effects of captopril (an ACEI) and losartan (an ARA-AT1 receptor antagonist) on thermal and chemical induced nocioception by employing hot plate and acetic acid induced writhing tests respectively in mice. Inbred albino mice weighing between 25-30 g were used and they were divided into two sets, each set containing 7 groups. Control groups received normal saline and the remaining six groups received three doses (0.5, 1 and 2 mg/kg) of captopril and three doses (0.5, 1 and 2 mg/kg) of losartan. Drugs were administered intraperitoneally fifteen minutes before placing the animal over the hot plate or 30 minutes before injecting 0.6% acetic acid. Both drugs dose dependently reduced the reaction time in hot plate method. In chemical induced writhing test, both the drugs reduced the latency of onset of writhing and in captopril pretreated groups, acetic acid induced sustained abdominal contraction without any intermittent relaxation. However, in losartan pretreated animals acetic acid just increased the number of writhings without sustained abdominal contraction. Thus, our study suggests that both drugs have hyperalgesic effects.en_US
dc.description.affiliationDepartment of Pharmacology, Kasturba Medical College, Mangalore 575 001.en_US
dc.identifier.citationRohit , Rao C, Krishna G. Effects of captopril and losartan on thermal and chemical induced pain in mice. Indian Journal of Physiology and Pharmacology. 2006 Apr-Jun; 50(2): 169-74en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107967
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAngiotensin II --physiologyen_US
dc.subject.meshAngiotensin II Type 1 Receptor Blockers --pharmacologyen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCaptopril --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHyperalgesia --chemically induceden_US
dc.subject.meshLosartan --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshReaction Time --drug effectsen_US
dc.titleEffects of captopril and losartan on thermal and chemical induced pain in mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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