Immune response in acute coronary syndromes.

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dc.contributor.authorJan, Ven_US
dc.contributor.authorJalal, Sen_US
dc.contributor.authorAslam, Ken_US
dc.contributor.authorIqbal, Ken_US
dc.contributor.authorTramboo, Nen_US
dc.contributor.authorAlai, M Sen_US
dc.contributor.authorRather, Hen_US
dc.contributor.authorLone, Nen_US
dc.date.accessioned1999-09-18en_US
dc.date.accessioned2009-05-27T04:22:19Z
dc.date.available1999-09-18en_US
dc.date.available2009-05-27T04:22:19Z
dc.date.issued1999-09-18en_US
dc.description.abstractInflammatory response in the atherosclerotic lesions of coronary artery disease, mediated by cellular immune mechanisms is well appreciated. The significance of the immuno-inflammatory processes for the development of acute ischaemic sequelae of these lesions remains unsettled. Fifty patients of acute coronary syndromes were studied for complement components and immunoglobin levels by single radial immunodiffusion method. Twenty-eight patients of acute myocardial infarction showed significantly lower levels of complement components C3 and C4 at admission (C3--69.19 +/- 12.91 mg% compared to 82.40 +/- 9.26 mg% in controls, p < 0.01; C4--14.56 +/- 2.46 mg% compared to 18.53 +/- 2.69 mg% in controls, p < 0.01). Twenty-two patients of unstable angina did not show any significant change (C3--83.14 +/- 8.01 mg% and C4--19.07 +/- 4.47 mg%). Sixteen patients of acute myocardial infarction who were thrombolysed with streptokinase showed a steep rise in the levels of complement components immediately after thrombolysis (C3--69.19 +/- 12.91 mg% before and 100.56 +/- 17.09 mg% after thrombolysis, p < 0.001; C4--14.56 +/- 2.46 mg% before and 21.48 +/- 4.78 mg% after thrombolysis, p < 0.001). Plasma C3 and C4 levels in acute myocardial infarction showed no relationship with peak CPK levels. Plasma immunoglobulins remained unchanged in patients of acute coronary syndromes.en_US
dc.description.affiliationDepartment of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar.en_US
dc.identifier.citationJan V, Jalal S, Aslam K, Iqbal K, Tramboo N, Alai MS, Rather H, Lone N. Immune response in acute coronary syndromes. Indian Heart Journal. 1999 Sep-Oct; 51(5): 515-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4244
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAngina, Unstable --drug therapyen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshComplement C3 --immunologyen_US
dc.subject.meshComplement C4 --immunologyen_US
dc.subject.meshCreatine Kinase --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolytic Agents --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Infarction --drug therapyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshStreptokinase --therapeutic useen_US
dc.subject.meshThrombolytic Therapyen_US
dc.titleImmune response in acute coronary syndromes.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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