Late onset adrenal hyperplasia due to 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency in north Indian hirsute women.

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dc.contributor.authorSundararaman, P Gen_US
dc.contributor.authorAmmini, A Cen_US
dc.contributor.authorKhurana, M Len_US
dc.contributor.authorKarmarkar, M Gen_US
dc.contributor.authorAhuja, M Men_US
dc.date.accessioned1997-01-01en_US
dc.date.accessioned2009-05-27T07:22:27Z
dc.date.available1997-01-01en_US
dc.date.available2009-05-27T07:22:27Z
dc.date.issued1997-01-01en_US
dc.description.abstractThe presence of late onset 3 beta-hydroxy steroid dehydrogenase (3 beta-HSD) type of congenital adrenal hyperplasia was studied in 58 north Indian hirsute women. The age range of these patients was 15 to 42 yr. Fifty two per cent of these patients had body mass index > 25. Basal serum testosterone, luteinizing hormone, follicle stimulating hormone, dehydroepiandrosterone sulphate (DHEAS), and 17 hydroxy progesterone (17 OHP) were estimated. All the patients underwent adrenocorticotropin (ACTH) stimulation test after an overnight dexamethasone suppression for the estimation of DHEAS, 17 OHP, and 17 hydroxy pregnenolone (delta 5-17p). Five (8.6%) hirsute women showed an exaggerated 17 OHP response to ACTH indicating 21-hydroxylase deficiency. Eight (13.8%) hirsute women had elevated basal DHEAS and ACTH-stimulated DHEAS as well as delta 5-17P responses indicative of 3 beta-HSD deficiency. In one patient hirsutism was the presenting manifestation of tumoural hyperandrogenism. Our findings indicate the presence of both 21-hydroxylase and 3 beta-HSD deficiency in north Indian hirsute women, with, 3 beta-HSD deficiency being the major cause of hirsutism in this population.en_US
dc.description.affiliationDepartment of Endocrinology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSundararaman PG, Ammini AC, Khurana ML, Karmarkar MG, Ahuja MM. Late onset adrenal hyperplasia due to 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency in north Indian hirsute women. Indian Journal of Medical Research. 1997 Jan; 105(): 27-31en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20443
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdrenal Hyperplasia, Congenital --complicationsen_US
dc.subject.meshAdulten_US
dc.subject.meshAge of Onseten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHirsutism --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshProgesterone Reductase --deficiencyen_US
dc.titleLate onset adrenal hyperplasia due to 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency in north Indian hirsute women.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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