Insulin regulates ionic metabolism in a fresh water teleost, anabas testudineus (bloch).

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dc.contributor.authorVijayasree, A Sen_US
dc.contributor.authorDivya, Len_US
dc.contributor.authorSreejith, Pen_US
dc.contributor.authorCyril, Jen_US
dc.contributor.authorSmita, Men_US
dc.contributor.authorOommen, O Ven_US
dc.date.accessioned2009-05-28T11:42:16Z
dc.date.available2009-05-28T11:42:16Z
dc.date.issued2005-08-27en_US
dc.description.abstractShort term effects of insulin on total brain and branchial Na+K+ ATPase, Ca2+ ATPase and Na+, K+ and Ca2+ ions were investigated in A. testudineus. The increase in brain Ca2+ ATPase after alloxan treatment may account for an increased amount of intracellular calcium required for biochemical events taking place inside the cells. Branchial Na+K+ATPase was significantly stimulated while Ca2+ ATPase significantly inhibited after alloxan treatment. This suggests that alloxan exerts its inhibitory effect on the ATP-driven Ca2+ transport via; its action on the Ca2+ pump protein rather than the membrane permeability to Ca2+. The increased activity of brain Na+K+ ATPase at 3 and 24 hr by insulin to alloxan pretreated fish may account for the stimulated co-transport of glucose and its utilization for energy requirements and the excitatory action on neurons in the brain. The elevated brain Ca2+ ATPase may be due to the role of calcium as a second messenger in hormone action. At 24 hr, the activity of branchial Na+K+ ATPase and Ca2+ ATPase in alloxan pretreated specimens was significantly stimulated by insulin. This may be due to increased synthesis of these enzyme units. Administration of insulin (lU/fish) in normal fish significantly inhibited the activity of brain and branchial Na+K+ ATPase while brain Ca2+ ATPase showed a stimulatory effect at 3 and 24 hr compared to control. Inhibition of total branchial Ca2+ ATPase activity by insulin may be due to increased Ca2+ concentration. Higher plasma glucose level in alloxan treated groups confirms the diabetic effect of alloxan. Insulin reverses this effect. The possible mechanism by which insulin controls Na+K+ ATPase activity appears to be tissue specific. The results seem to be the first report on the effect of insulin on ATPase activity in a teleost. These data are consistent with the hypothesis that insulin performs a role in hydro mineral regulation in freshwater teleosts.en_US
dc.description.affiliationDepartment of Zoology, University of Kerala, Kariavattom, Thiruvananthapuram 695 581, India.en_US
dc.identifier.citationVijayasree AS, Divya L, Sreejith P, Cyril J, Smita M, Oommen OV. Insulin regulates ionic metabolism in a fresh water teleost, anabas testudineus (bloch). Indian Journal of Experimental Biology. 2005 Aug; 43(8): 702-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57084
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAlloxan --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshBrain --drug effectsen_US
dc.subject.meshCalcium --metabolismen_US
dc.subject.meshCalcium-Transporting ATPases --metabolismen_US
dc.subject.meshFish Proteins --metabolismen_US
dc.subject.meshGills --drug effectsen_US
dc.subject.meshInsulin --pharmacologyen_US
dc.subject.meshIons --metabolismen_US
dc.subject.meshPerciformes --metabolismen_US
dc.subject.meshPotassium --metabolismen_US
dc.subject.meshSodium --metabolismen_US
dc.subject.meshSodium-Potassium-Exchanging ATPase --metabolismen_US
dc.titleInsulin regulates ionic metabolism in a fresh water teleost, anabas testudineus (bloch).en_US
dc.typeJournal Articleen_US
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