Comparative Evaluation of Quality of Life in Patients of Head and Neck Carcinoma withRadiation Induced Skin-injury in Oncology Department at Tertiary Care Hospital
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Date
2019-01
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Journal ISSN
Volume Title
Publisher
Medical Council of India
Abstract
Radiation mitigators are the compounds which can minimize post irradiation-toxicity provided theyare administered before the onset of toxic symptoms. In present study we compared pre and posttreatment quality of life in head and neck cancer patients receiving radiotherapy.Sixty patients ofHead and neck carcinoma more than 18 years of age of either sex and willing to give informedconsent were included in the study. In Group-1, 30 patients received the Beclomethasone cream thatwas topically applied from the day-1 of radiotherapy till 4-weeks after completion of radiotherapy,whereas In Group-2, 30 patients received the local application of the herbal paste from the day-1 ofradiotherapy till 4-weeks after completion of radiotherapy. These 60 patients were evaluated at 6month post-therapy using the European organisation for research and treatment of cancer quality oflife questionnaire C30 .For measuring radiation-induced reactions, chi-square test was applied andnumber of patients in different grades was calculated as per Radiotherapy oncology group criteria.Similarly for measuring radiation-induced mucosal reactions, non-parametric test i.e chi-square testwas applied and number of patients in different grades was calculated as per radiotherapy oncologygroup criteria. As per quality of life questionnaire, evaluation on symptom scale revealed that fatigue,pain, dyspnoea, appetite loss and insomnia got worsened in Gp-1 patients, except for diarrhoea,constipation and nausea or vomiting while in Gp-2 patients, all symptoms showed improvement after6 month of completion of treatment. Comparing pre and post-treatment , the global health statusshowed statistically significant improvement in group-2 patients receiving polyherbal paste .The International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS), 2019, Vol 6, No.1,65-79. 66present study revealed a beneficial effects of polyherbal paste containing Azadirachta indica, aloevera, Ocimum sanctum and Curcuma longa on radiation induced skin injury in patients with Head andneck carcinoma as compared to topical Beclomethasone cream. Also there was improvement inquality of life in cancer patients receiving herbal paste measured at 6 month post-treatment.
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Keywords
Beclomethasone dipropionate cream, ionizing radiation, Quality of life
Citation
Sharma Shalini, Sharma Vivek, Gupta MC, Verma Yashpal. Comparative Evaluation of Quality of Life in Patients of Head and Neck Carcinoma withRadiation Induced Skin-injury in Oncology Department at Tertiary Care Hospital. International Journal of Interdisciplinary and Multidisciplinary Studies. 2019 Jan; 6(1): 65-79