Effect of granulocyte macrophage colony stimulating factor on hepatitis-B vaccination in haemodialysis patients.

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dc.contributor.authorSudhagar, Ken_US
dc.contributor.authorChandrasekar, Sen_US
dc.contributor.authorRao, M Sen_US
dc.contributor.authorRavichandran, Ren_US
dc.date.accessioned1999-06-22en_US
dc.date.accessioned2009-05-31T04:20:29Z
dc.date.available1999-06-22en_US
dc.date.available2009-05-31T04:20:29Z
dc.date.issued1999-06-22en_US
dc.description.abstractOBJECTIVES: Haemodialysis patients often fail to respond to hepatitis B vaccination. There are various agents that can be used as vaccine adjuvant in chronic renal failure patients on haemodialysis. In this study, the adjuvant effect of granulocyte macrophage colony stimulating factor (GMCSF) is compared with that of control subjects. METHODS: In this study, eight patients were started on 150 mcg of GMCSF subcutaneously 24 hours prior to intramuscular hepatitis B vaccination (20 mcg of genetically engineered vaccine at the same site). The antibody response to surface antigen (anti HBsAg) in these patients were compared with those of eight control subjects who received standard three doses of monthly 40 mcg of same hepatitis B vaccine. RESULTS: In the control study, only two patients developed significant antibody response to surface antigen whereas seven of eight patients in GMCSF group developed significant antibody titres (> 10 IU/L). The sero-protection rate was 87.5% in GMCSF group and 25% in control group. CONCLUSION: This study shows that GMCSF offers significantly better seroprotection against hepatitis B compared to standard dose of vaccination in patients with chronic renal failure on haemodialysis.en_US
dc.description.affiliationMadras Institute of Nephrology, Vijaya Health Centre, Chennai.en_US
dc.identifier.citationSudhagar K, Chandrasekar S, Rao MS, Ravichandran R. Effect of granulocyte macrophage colony stimulating factor on hepatitis-B vaccination in haemodialysis patients. Journal of the Association of Physicians of India. 1999 Jun; 47(6): 602-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/94669
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdjuvants, Immunologic --administration & dosageen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor --administration & dosageen_US
dc.subject.meshHepatitis B Vaccines --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRenal Dialysisen_US
dc.titleEffect of granulocyte macrophage colony stimulating factor on hepatitis-B vaccination in haemodialysis patients.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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