Efficacies of Reverse Hybrid Therapy in Eradication of Helicobacter pylori Infection

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dc.contributor.authorGupta, Pradeep Kumaren_US
dc.contributor.authorManocha, Keertien_US
dc.date.accessioned2020-09-24T07:11:19Z
dc.date.available2020-09-24T07:11:19Z
dc.date.issued2019-11
dc.description.abstractIntroduction: Because the prevalence of antibiotic resistancemarkedly increases with time worldwide, anti-H. pyloritreatment is continuing to be a great challenge for physiciansin clinical practice. Eradication of H. pylori infection markedlychanges the natural history of peptic ulcer in patients withduodenal or gastric ulcer. Most peptic ulcers associated withH. pylori infection are curable. Aim of present study was tostudy the efficacies of 14 days ‘ Reverse Hybrid Therapy’ inH.pylori positive G.I.patients.Material and methods: 100 H.pylori positive patients withupper G.I. complaints who underwent upper GI endoscopywere included in the study. H.pylori infection was documentedby at least 2 positive results of Rapid Urease Test. Subjectswith any of the following criteria were excluded from thestudy. 1. Previous eradication therapy 2. Allergy to anyantibiotic used in study. 3. Co- existence of any serious illness.4. Pregnancy or lactating women 5. Previous gastrectomy6. Use of antibiotics within last 4 week. Detailed medicalhistory and demographic details of the patients were recorded.Routine haematogical tests and USG was done. Patients weregiven 14 days dual therapy ie quadruple regimen (proton pumpinhibitor + amoxicillin + clarithromycin + metronidazole) forfirst 7 days followed by dual regimen of PPI+ amoxicillin fornext 7 days. Patients were asked to report at 7, 14 days and at6 weeks interval.Results: Out of 97 patients 93 patients became negative forH.pylori after 6 week of Reverse Hybrid eradication therapy.It was observed that majority of patients enrolled in the studywere in the age group of 41–60 years (50%) followed bybelow 40 yrs (27%), above 60 yrs (23%). Out of them, 74%were male and 26% were female.Conclusion: Out of 97 patients 93 patients became negativefor H.pylori after 6 week of Reverse Hybrid eradicationtherapy. Hence, Reverse Hybrid Therapy is equally potenttherapy to Bismuth based therapy though the latter has a lotof side effects.en_US
dc.identifier.affiliationsAssociate Professor, Department of Medicine, Subharti Medical College, Meeruten_US
dc.identifier.affiliationsResident, Department of Medicine, Subharti Medical College, Meerut, Indiaen_US
dc.identifier.citationGupta Pradeep Kumar, Manocha Keerti. Efficacies of Reverse Hybrid Therapy in Eradication of Helicobacter pylori Infection. International Journal of Contemporary Medical Research . 2019 Nov; 6(11): k4-k6en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202656
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber11en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.11.9en_US
dc.subjectH. pylorien_US
dc.subjectRapid Urease Testen_US
dc.subjectProton Pump Inhibitoren_US
dc.subjectAmoxicillinen_US
dc.subjectClarithromycinen_US
dc.subjectMetronidazoleen_US
dc.subjectReverse Hybrid Eradication Therapyen_US
dc.titleEfficacies of Reverse Hybrid Therapy in Eradication of Helicobacter pylori Infectionen_US
dc.typeJournal Articleen_US
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