Comparison of altered fractionation schedule with concurrent chemo-radiation for squamous cell carcinoma of head and neck

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dc.contributor.authorK., Mathew Vargheseen_US
dc.contributor.authorNarayanan, Geeta S.en_US
dc.contributor.authorVishwanathan, Bhaskaren_US
dc.contributor.authorKarpurmath, Shashidhar V.en_US
dc.contributor.authorNarayanan, Soumyaen_US
dc.date.accessioned2020-11-18T10:02:14Z
dc.date.available2020-11-18T10:02:14Z
dc.date.issued2020-08
dc.description.abstractBackground: Aim of the study was to compare the response of altered fractionation schedule with concurrent chemo-radiation in patients with primary and the nodal disease.Methods: Total of 40 patients (20 in each arm) with stage 1- 4 squamous cell carcinoma of the head and neck with a performance status of 0-2 (ECOG) were included in the study. Arm A was altered fractionation schedule where in patients received 6 fractions per week to a total dose of 6600 cGy in 33 fractions. In Arm B, patients received conventional radiotherapy with concurrent chemotherapy three weekly Inj. of cisplatin (100 mg/m2). Patients were evaluated for acute toxicity every week using the Acute Radiation Morbidity Scoring Criteria. The response was assessed after 6 weeks and 12 weeks post treatment using the RECIST criteria. Data was statistically analyzed.Results: Seventeen patients in Arm A and 18 patients in Arm B completed the treatment. At the end of three months, In Arm A, 7 patients had complete response and in Arm B, 9 patients had complete response of the primary (p>0.05).  When the complete nodal response was compared in both the arms, there was no difference (2 vs 4 in Arm A vs Arm B resp.). But there were more partial nodal responders in Arm B (p = 0.016). The acute toxicities were comparable in both the arms.Conclusions: Altered fraction radiotherapy can be used in early lesions with minimal nodal burden but with locally advanced disease or large nodal burden addition of chemotherapy should not be avoided.en_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Amala Institute of Medical Sciences, Thrissur-680 555, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Vydehi Institute of Medical Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Oncology, Vydehi Institute of Medical Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Physics, Vydehi Institute of Medical Sciences, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationK. Mathew Varghese, Narayanan Geeta S., Vishwanathan Bhaskar, Karpurmath Shashidhar V., Narayanan Soumya. Comparison of altered fractionation schedule with concurrent chemo-radiation for squamous cell carcinoma of head and neck. International Journal of Research in Medical Sciences. 2020 Aug; 8(8): 2834-2838en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212515
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber8en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20203095en_US
dc.subjectAcute toxicityen_US
dc.subjectAltered fractionationen_US
dc.subjectConcurrent chemo-radiationen_US
dc.subjectRadiotherapyen_US
dc.subjectSquamous cell carcinoma of head and necken_US
dc.titleComparison of altered fractionation schedule with concurrent chemo-radiation for squamous cell carcinoma of head and necken_US
dc.typeJournal Articleen_US
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