Possible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice.

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dc.contributor.authorChugh, Yen_US
dc.contributor.authorSankaranarayanan, Aen_US
dc.contributor.authorSharma, P Len_US
dc.date.accessioned1994-04-01en_US
dc.date.accessioned2009-06-01T07:59:36Z
dc.date.available1994-04-01en_US
dc.date.available2009-06-01T07:59:36Z
dc.date.issued1994-04-01en_US
dc.description.abstractThe effects of pre-training and post-training administration of endosulfan on retention of a step-down passive avoidance task was studied in mice. Endosulfan at doses of 1.0 mg/kg(ip) and 2.0 mg/kg(ip) enhanced memory acquisition and retention. This effect of endosulfan was possibly mediated by interaction with cholinergic neurotransmission, as scopolamine (0.5 mg/kg, ip) significantly antagonized the memory enhancing effects of endosulfan. Clonidine (0.05 mg/kg, ip) did not have any effect on enhancement of memory produced by endosulfan, thus indicating possibly no role of noradrenergic system.en_US
dc.description.affiliationDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh.en_US
dc.identifier.citationChugh Y, Sankaranarayanan A, Sharma PL. Possible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice. Indian Journal of Physiology and Pharmacology. 1994 Apr; 38(2): 138-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108577
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAvoidance Learning --drug effectsen_US
dc.subject.meshClonidine --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEndosulfan --administration & dosageen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshMaleen_US
dc.subject.meshMemory --drug effectsen_US
dc.subject.meshMiceen_US
dc.subject.meshScopolamine --pharmacologyen_US
dc.subject.meshSynaptic Transmission --drug effectsen_US
dc.titlePossible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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