Psoriasis in autoimmune polyendocrine syndrome type I: A possible complication or a non-endocrine minor component.

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dc.contributor.authorPoojary, Shital Amin
dc.contributor.authorLodha, Nikita
dc.contributor.authorGupta, Nikita
dc.date.accessioned2015-06-24T06:41:44Z
dc.date.available2015-06-24T06:41:44Z
dc.date.issued2015-03
dc.description.abstractIntroduction: Autoimmune polyendocrine syndrome type I (APS I) is an autosomal recessive systemic autoimmune disorder, affecting primarily endocrine glands, in which chronic mucocutaneous candidiasis is an early and prominent manifestation. We describe the rare occurrence of unstable psoriasis (with onset of pustular lesions) in a case of APS I without mucocutaneous candidiasis. A patient presenting with unstable psoriasis (with onset of pustular lesions) was detected to have persistent hypocalcemia which led to the diagnosis of hypoparathyroidism. Subsequently he was found to have hypergonadotrophic hypogonadism, primary adrenal insuffi ciency (compensated), and coeliac disease, thus confi rming the diagnosis of APS I. Psoriasis is very rarely reported in APS I, possibly due to the protective effect of antibodies to Th17 cytokines, which are responsible for the occurrence of candidiasis in this syndrome. However, psoriasis could occur in APS I patients without mucocutaneous candidiasis, who lack these antibodies. In our patient, possible factors aggravating psoriasis include hypocalcemia due to hypoparathyroidism as well as coeliac disease via anti-tissue transglutaminase antibodies. However, defi ning psoriasis as a possible minor component of APS I would require further studies of the autoimmune regulator (AIRE) gene functions.en_US
dc.identifier.citationPoojary Shital Amin, Lodha Nikita, Gupta Nikita. Psoriasis in autoimmune polyendocrine syndrome type I: A possible complication or a non-endocrine minor component. Indian Journal of Dermatology, Venereology and Leprology. 2015 Mar-Apr; 81(2): 166-169.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158271
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2015;volume=81;issue=2;spage=166;epage=169;aulast=Poojaryen_US
dc.subjectAutoimmune polyendocrine syndrome Ien_US
dc.subjectcandidiasisen_US
dc.subjectpsoriasisen_US
dc.subject.meshAdult
dc.subject.meshCandidiasis --complications
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPolyendocrinopathies, Autoimmune --classification
dc.subject.meshPolyendocrinopathies, Autoimmune --complications
dc.subject.meshPsoriasis --diganosis
dc.subject.meshPsoriasis --etiology
dc.titlePsoriasis in autoimmune polyendocrine syndrome type I: A possible complication or a non-endocrine minor component.en_US
dc.typeArticleen_US
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