Role of Gene Polymorphism in TNF Alpha Expression and Outcome in Surgical Patients

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dc.contributor.authorReddy, E. Vimalakaren_US
dc.contributor.authorV., Sureshen_US
dc.contributor.authorMohan, Ramen_US
dc.contributor.authorHassan, Annie Q.en_US
dc.contributor.authorPrasad, G. R.en_US
dc.contributor.authorG., Satyanarayanaen_US
dc.date.accessioned2020-10-16T08:53:13Z
dc.date.available2020-10-16T08:53:13Z
dc.date.issued2020-09
dc.description.abstractIntroduction:An acute phase response to tissue injury leads to release of pro inflammatory and anti inflammatory cytokines. TNF alpha isan early pro inflammatory cytokine that released in SIRS and largely responsible for clinical manifestation of sepsis. The release of TNF alpha is influenced by messenger RNA transcription of TNF alpha gene. In patients with severe sepsis genomic polymorphism with in the TNF locus found to be associated with TNF alpha production and outcome.Objectives:To evaluate genetic polymorphism of TNF alpha gene at c 850 t locus, influence on TNF alpha expression and on outcome. Materials and Methods:A prospective cohort study conducted at our institute between June 2007 to 2009 in 100 cases. Serum TNF alpha levels measured by using ELISA .TNF alpha polymorphism done at c850t locus in 100 patients and were compared with 70 controls who were normal subjects. By using MEDCALC software mean and standard deviations were calculated, continuous variables were compared using t-test. ROC curves were used to determine the predictive capability of the variables.Results:The most common polymorphism observed was CT in 51 patients. The significant different TNF alpha level expression between the three groups were observed. Significant Tallele was observed in cases (100) when compared with controls (70), p= 0.0002. Conclusion: Genetic polymorphism of TNF alpha gene may play critical role in stress response and outcome of the patient but it needs to be validated in large number of populationen_US
dc.identifier.affiliationsDepartment of General Surgery, Kamineni Hospitals, Hyderabad, Andhra Pradesh, Indiaen_US
dc.identifier.citationReddy E. Vimalakar, V. Suresh, Mohan Ram, Hassan Annie Q., Prasad G. R., G. Satyanarayana. Role of Gene Polymorphism in TNF Alpha Expression and Outcome in Surgical Patients. Journal of Advances in Medicine and Medical Research. 2020 Sep; 32(15): 1-5en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210256
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber15en_US
dc.relation.volume32en_US
dc.source.urihttps://dx.doi.org//10.9734/JAMMR/2020/v32i1530599en_US
dc.subjectTumor necrosis factor alphaen_US
dc.subjectgene polymorphismen_US
dc.subjectmajor surgery.en_US
dc.titleRole of Gene Polymorphism in TNF Alpha Expression and Outcome in Surgical Patientsen_US
dc.typeJournal Articleen_US
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